ID A0A2K5MB79_CERAT Unreviewed; 553 AA.
AC A0A2K5MB79;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=NADPH oxidase 4 {ECO:0000313|Ensembl:ENSCATP00000022454.1};
GN Name=NOX4 {ECO:0000313|Ensembl:ENSCATP00000022454.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000022454.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000022454.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_011931020.1; XM_012075630.1.
DR AlphaFoldDB; A0A2K5MB79; -.
DR Ensembl; ENSCATT00000046663.1; ENSCATP00000022454.1; ENSCATG00000034813.1.
DR GeneID; 105592967; -.
DR KEGG; caty:105592967; -.
DR CTD; 50507; -.
DR GeneTree; ENSGT00940000159621; -.
DR OrthoDB; 367877at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000034813; Expressed in adult mammalian kidney and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050664; F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor; IEA:UniProt.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:UniProt.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR InterPro; IPR000778; Cyt_b245_heavy_chain.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR PANTHER; PTHR11972:SF209; NADPH OXIDASE 4; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR PRINTS; PR00466; GP91PHOX.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 279..394
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 553 AA; 63582 MW; CA83D5249C29DA36 CRC64;
MLTAVTGLGS IESTMAKNLP VVSIHQLGLC LSRASASVLN LNCSLILLPM CRILLAFLRG
SQKVPSRRTR RLLDKSRTFH ITCGVTICIF SGVHVAAHLV NALNFSVNYS EDFVELNAAR
YRNEDPRKLL FMTVPGLTGV CMVVVLFLMI TASTYAIRVS NYDIFWYTHN LFFVFYVLLM
LHVSGGLLKY QTNLDTHPPG CINLNRTSSQ NISLPEYFSE HFHEPFPEEF SKPEEFTQNT
FVKICMEEPR FQANFPQTWL WISGPLCLYC AERLYRYIRS NKPVTIISVI SHPSDVMEIR
MVKENFKARP GQYIILHCPS VSALENHPFT LTMCPTETKA TFGVHLKIVG DWTERFRDLL
LPPSSQDSEI LPFIQSRNYP KLYIDGPFGS PFEESLNYEI SLCVAGGIGV TPFASILNTL
LDDWKPYKLR RLYFIWVCRD IQSFRWFADL LCMLHNKFWQ ENRPDYVNIQ LYLSQTDGIQ
KIIGEKYHAL NSRLFIGRPR WKLLFDEIAK YNRGKTVGVF CCGPNSLSKT LHKLSNQNNS
YGTRFEYNKE SFS
//
