ID A0A2K5MBK1_CERAT Unreviewed; 84 AA.
AC A0A2K5MBK1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=CDC42 small effector protein 2 {ECO:0000256|ARBA:ARBA00039939};
GN Name=CDC42SE2 {ECO:0000313|Ensembl:ENSCATP00000022552.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000022552.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000022552.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probably involved in the organization of the actin
CC cytoskeleton by acting downstream of CDC42, inducing actin filament
CC assembly. Alters CDC42-induced cell shape changes. In activated T-
CC cells, may play a role in CDC42-mediated F-actin accumulation at the
CC immunological synapse. May play a role in early contractile events in
CC phagocytosis in macrophages. {ECO:0000256|ARBA:ARBA00025235}.
CC -!- SUBUNIT: Interacts with CDC42 (in GTP-bound form). Interacts weakly
CC with RAC1 and not at all with RHOA. {ECO:0000256|ARBA:ARBA00025895}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004193};
CC Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the CDC42SE/SPEC family.
CC {ECO:0000256|ARBA:ARBA00005720}.
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DR RefSeq; XP_011945533.1; XM_012090143.1.
DR RefSeq; XP_011945534.1; XM_012090144.1.
DR RefSeq; XP_011945535.1; XM_012090145.1.
DR RefSeq; XP_011945536.1; XM_012090146.1.
DR AlphaFoldDB; A0A2K5MBK1; -.
DR STRING; 9531.ENSCATP00000022552; -.
DR Ensembl; ENSCATT00000046763.1; ENSCATP00000022552.1; ENSCATG00000034894.1.
DR GeneID; 105599719; -.
DR KEGG; caty:105599719; -.
DR CTD; 56990; -.
DR GeneTree; ENSGT00940000158245; -.
DR OMA; IGVPTNF; -.
DR OrthoDB; 2787572at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000034894; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00132; CRIB; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR039056; SPEC.
DR PANTHER; PTHR13502:SF4; CDC42 SMALL EFFECTOR PROTEIN 2; 1.
DR PANTHER; PTHR13502; CDC42 SMALL EFFECTOR PROTEIN HOMOLOG; 1.
DR Pfam; PF00786; PBD; 1.
DR PROSITE; PS50108; CRIB; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 29..42
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
SQ SEQUENCE 84 AA; 9223 MW; 98C5E82176DA990A CRC64;
MSEFWLCFNC CIAEQPQPKR RRRIDRSMIG EPTNFVHTAH VGSGDLFSGM NSVSSIQNQM
QSKGGYGGGM PANVQMQLVD TKAG
//