ID   A0A2K5MC67_CERAT        Unreviewed;       821 AA.
AC   A0A2K5MC67;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=MutS homolog 5 {ECO:0000313|Ensembl:ENSCATP00000022806.1};
GN   Name=MSH5 {ECO:0000313|Ensembl:ENSCATP00000022806.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000022806.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000022806.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000256|ARBA:ARBA00006271}.
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DR   AlphaFoldDB; A0A2K5MC67; -.
DR   Ensembl; ENSCATT00000047018.1; ENSCATP00000022806.1; ENSCATG00000034981.1.
DR   GeneTree; ENSGT00550000074977; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000034981; Expressed in thymus and 6 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0007127; P:meiosis I; IEA:UniProt.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd03281; ABC_MSH5_euk; 1.
DR   Gene3D; 1.10.1420.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   PANTHER; PTHR11361:SF20; MUTS PROTEIN HOMOLOG 5; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF005813; MSH2; 2.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT   DOMAIN          653..669
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|PROSITE:PS00486"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   821 AA;  91116 MW;  64D03B5DDC3F8CC3 CRC64;
     MASLGVNPSR TPQGPGHGAA SSGFSSPAPV AGPREAEEEE VEEEEELAEI HLCVLWNSGY
     MGIAYYDTSD STIHFMPDAP DHESLKLLQR VLDEINPQSV VTSAKQDENM TRFLGKLASQ
     EHRQPKRPEI VFLPSVDFGL EISKQRLLSG NYSFIPDSMT ATEKILFLSS IIPFDCLLTV
     RALGGLLKFL GRRRIGVELE DYNVSVPILG FKKFMLTHLV NIDQDTYSVL QIFKSESHPS
     AYKVASGLKE GLSLFGILNR CRCKRGEKLL RLWFTRPTHD LGELNSRLDV IQFFLLPQNL
     DMAQMLHRLL GHIKNVPLIL KRMKLSHTKV SDWQVLYKTV YGALGLRDAC RSLPQSIQLF
     RDIAQEFSDD LHHIASLIGK VVDFEGSLAE NRFTVLPNID PEIDEKKRRL MGLPSFLTEV
     ARKELENLDS RIPSCSVIYI PLIGFLLSIP RLPFMVEASD FEINGLDFMQ LREGLTLHSL
     PHPLPDQETL LMYQLQCQVL ARAAVLTQVL DLASRLDVLL ALASAARDYG YSRPRYSPQV
     LGVRIQNGRH PLMELCARTF VPNSTECGGD KGRVKVITGP NSSGKSIYLK QVGLITFMAL
     VGSFVPAEEA EIGAVDAIFT RIHSCESISL GLSTFMIDLN QVAKAVNNAT AQSLVLIDEF
     GKGTNTVDGL ALLAAVLRHW LARGPTCPHI FVATNFLSLV QLQLLPQGPL VQYLTMETCE
     DGNDLVFFYQ VCEGVAKASH ASHTAAQAGL PDKLVARGKE VSDLIRSGKP IKPVKDLLKK
     NQMENCQTLV DKFMKLDLED PNLDLNIFMS QEVLSAATSI L
//