ID A0A2K5MD71_CERAT Unreviewed; 589 AA.
AC A0A2K5MD71;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Checkpoint kinase 2 {ECO:0000313|Ensembl:ENSCATP00000023161.1};
GN Name=CHEK2 {ECO:0000313|Ensembl:ENSCATP00000023161.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000023161.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000023161.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5MD71; -.
DR STRING; 9531.ENSCATP00000023161; -.
DR Ensembl; ENSCATT00000047375.1; ENSCATP00000023161.1; ENSCATG00000035122.1.
DR GeneTree; ENSGT00800000124190; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000035122; Expressed in bone marrow and 10 other cell types or tissues.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0071480; P:cellular response to gamma radiation; IEA:Ensembl.
DR GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Ensembl.
DR GO; GO:0006302; P:double-strand break repair; IEA:Ensembl.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IEA:Ensembl.
DR GO; GO:0090307; P:mitotic spindle assembly; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0070242; P:thymocyte apoptotic process; IEA:Ensembl.
DR CDD; cd22666; FHA_CHK2; 1.
DR CDD; cd14084; STKc_Chk2; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR44167; OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED; 1.
DR PANTHER; PTHR44167:SF9; SERINE_THREONINE-PROTEIN KINASE CHK2; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR02045; F138DOMAIN.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 159..221
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 266..532
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 65918 MW; 3B2989184E7D14C1 CRC64;
MSRESDVEAQ QSHGSSTCSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
SSLETVSTQE LYSIPEDQEP EDQEPEEPAP APWARLWALQ DGFANLETES RHVTQSDLEL
LVSTDPPASA SQSAGIRGVR HHLRPVFSLL SLKCVNDNYW FGRDKSCEYC FDEPLLKRTD
KYRTYSKKHF RIFREVGPKN SYIAYIEDHS GNGTFVNTEL VGKGKRRPLN NNSEIALSLS
RNKVFVFFDL TVDDQSVYPK ALRDEYIMSK TLGSGACGEV KLAFERKTCK KVAIKIISKR
KFAIGSARET DPALNVETEI EILKKLNHPC IIKIKNFFDA EDYYIVLELM EGGELFDKVV
GNKRLKEATC KLYFYQMLLA VQYLHENGII HRDLKPENVL LSSQEEDCLI KITDFGHSKI
LGETSLMRTL CGTPTYLAPE VLVSVGTAGY NRAVDCWSLG VILFICLSGY PPFSEHRTQV
SLKDQITSGK YNFIPEVWAE VSEKALDLVK KLLVVDPKAR FTTEEALRHP WLQDEDMKRK
FQDLLSEENE STALPQVLAQ PSTSRKRPHE GEAEGAETTK RLAVCAAVL
//
