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Database: UniProt
Entry: A0A2K5MDF8_CERAT
LinkDB: A0A2K5MDF8_CERAT
Original site: A0A2K5MDF8_CERAT 
ID   A0A2K5MDF8_CERAT        Unreviewed;       834 AA.
AC   A0A2K5MDF8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   11-DEC-2019, entry version 16.
DE   SubName: Full=Tripartite motif containing 28 {ECO:0000313|Ensembl:ENSCATP00000023237};
GN   Name=TRIM28 {ECO:0000313|Ensembl:ENSCATP00000023237};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000023237, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000023237, ECO:0000313|Proteomes:UP000233060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y., Hughes D.S., Murali S., Raveendran M., Korchina V., Wang M.,
RA   Jhangiani S., Bandaranaike D., Bellair M., Blankenburg K., Chao H.,
RA   Dahdouli M., Dinh H., Doddapaneni H., English A., Firestine M., Gross S.,
RA   Hernandez B., Javaid M., Jayaseelan J., Jones J., Joshi V., Khan Z.,
RA   Kovar C., Lee S., Newsham I., Nguyen L., Okwuonu G., Ongeri F., Osuji N.,
RA   Pu L.-L., Puazo M., Qu C., Quiroz J., Raj R., Reid J.G., Santibanez J.,
RA   Scheel M., Sexton D., Shah N., Skinner E., Vee V., Wu Y., Han Y.,
RA   Muzny D.M., Richards S., Worley K.C., Rogers J., Gibbs R.A.;
RT   "Sooty reference genome and diversity panel.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCATP00000023237}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
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DR   RefSeq; XP_011931713.1; XM_012076323.1.
DR   Ensembl; ENSCATT00000047452; ENSCATP00000023237; ENSCATG00000035178.
DR   GeneID; 105593288; -.
DR   CTD; 10155; -.
DR   GeneTree; ENSGT00940000160527; -.
DR   OMA; DANQQCC; -.
DR   OrthoDB; 756911at2759; -.
DR   Proteomes; UP000233060; Whole Genome Shotgun Assembly.
DR   GO; GO:0005719; C:nuclear euchromatin; IEA:Ensembl.
DR   GO; GO:0005720; C:nuclear heterochromatin; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0090575; C:RNA polymerase II transcription factor complex; IEA:Ensembl.
DR   GO; GO:0070087; F:chromo shadow domain binding; IEA:Ensembl.
DR   GO; GO:0035851; F:Krueppel-associated box domain binding; IEA:Ensembl.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR   GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR   GO; GO:0060028; P:convergent extension involved in axis elongation; IEA:Ensembl.
DR   GO; GO:0043045; P:DNA methylation involved in embryo development; IEA:Ensembl.
DR   GO; GO:0006281; P:DNA repair; IEA:Ensembl.
DR   GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
DR   GO; GO:0060669; P:embryonic placenta morphogenesis; IEA:Ensembl.
DR   GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR   GO; GO:1901536; P:negative regulation of DNA demethylation; IEA:Ensembl.
DR   GO; GO:0045869; P:negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:1902187; P:negative regulation of viral release from host cell; IEA:Ensembl.
DR   GO; GO:0043388; P:positive regulation of DNA binding; IEA:Ensembl.
DR   GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
DR   GO; GO:0090309; P:positive regulation of methylation-dependent chromatin silencing; IEA:Ensembl.
DR   GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
DR   GO; GO:0051259; P:protein complex oligomerization; IEA:Ensembl.
DR   GO; GO:0016925; P:protein sumoylation; IEA:Ensembl.
DR   GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR   GO; GO:2000653; P:regulation of genetic imprinting; IEA:Ensembl.
DR   CDD; cd00021; BBOX; 1.
DR   CDD; cd16765; RING-HC_TIF1beta; 1.
DR   Gene3D; 1.20.920.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR003649; Bbox_C.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR037373; KAP1.
DR   InterPro; IPR042713; TIF1beta_RING-HC.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR25462:SF274; PTHR25462:SF274; 1.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF00643; zf-B_box; 2.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00502; BBC; 1.
DR   SMART; SM00336; BBOX; 2.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00184; RING; 2.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS50119; ZF_BBOX; 2.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|SAAS:SAAS01011399};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Zinc {ECO:0000256|SAAS:SAAS01006535};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00024,
KW   ECO:0000256|SAAS:SAAS01007077}.
FT   DOMAIN          65..121
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          148..195
FT                   /note="B box-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50119"
FT   DOMAIN          204..245
FT                   /note="B box-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50119"
FT   DOMAIN          624..671
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          411..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          583..617
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          814..834
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..50
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   834 AA;  88557 MW;  E88F5C075BE68EEB CRC64;
     MAASAAAASA AAASAASGSP GPGESSAGGE KRSTASSTAA SASASASVSS PAGGGAEALE
     LLEHCGVCRE RLRPEREPRL LPCLHSACSA CLGPAAPAAA NSSGDGGAAG DGAVVDCPVC
     KQQCFSKDIV ENYFMRDSGS KAATDAQDAN QCCTSCEDNA PATSYCVECS EPLCETCVEA
     HQRVKYTKDH TVRSTGPAKS RDGERTVYCN VHKHEPLVLF CESCDTLTCR DCQLNAHKDH
     QYQFLEDAVR NQRKLLASLV KRLGDKHATL QKSTKEVRSS IRQVSDVQKR VQVDVKMAIL
     QIMKELNKRG RVLVNDAQKV TEGQQERLER QHWTMTKIQK HQEHILRFAS WALESDNNTA
     LLLSKKLIYF QLHRALKMIV DPVEPHGEMK FQWDLNAWTK SAEAFGKIVA ERPGTNSTGP
     APMAPPRAPG PLSKQGSGSS QPMEVQEGYG FGSDDPYSSA EPHVSGVKRS RSGEGEVSGL
     MRKVPRVSLE RLDLDLTADS QPPVFKVFPG STTEDYNLIV IERGAAAAAT GQPGTAPAGT
     PGAPPLAGMA IVKEEETEAA IGAPPTATEG PETKPVLMAL AEGPGAEGPR LASPSGSTSS
     GLEVVAPEGT SAPGGGPGTL DDSATICRVC QKPGDLVMCN QCEFCFHLDC HLPALQDVPG
     EEWSCSLCHV LPDLKEEDGS LSLDGADSTG VVAKLSPANQ RKCERVLLAL FCHEPCRPLH
     QLATDSTFSL DQPGGTLDLT LIRARLQEKL SPPYSSPQEF AQDVGRMFKQ FNKLTEDKAD
     VQSIIGLQRF FETRMNEAFG DTKFSAVLVE PPPMSLPGAG LSSQELSGGP GDGP
//
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