ID A0A2K5MEE9_CERAT Unreviewed; 1886 AA.
AC A0A2K5MEE9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Dedicator of cytokinesis 1 {ECO:0000313|Ensembl:ENSCATP00000023553.1};
GN Name=DOCK1 {ECO:0000313|Ensembl:ENSCATP00000023553.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000023553.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000023553.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_011898713.1; XM_012043323.1.
DR STRING; 9531.ENSCATP00000023553; -.
DR Ensembl; ENSCATT00000047771.1; ENSCATP00000023553.1; ENSCATG00000035320.1.
DR GeneID; 105578039; -.
DR CTD; 1793; -.
DR GeneTree; ENSGT00940000154974; -.
DR OMA; LWDNQAF; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000035320; Expressed in colon and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08694; C2_Dock-A; 1.
DR CDD; cd11707; DHR2_DOCK1; 1.
DR CDD; cd12051; SH3_DOCK1_5_A; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR047025; DOCK1_5_SH3.
DR InterPro; IPR047026; DOCK1_C2.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF1; DEDICATOR OF CYTOKINESIS PROTEIN 1; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 9..70
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 446..630
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1228..1638
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1640..1737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1774..1886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 185..212
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1654..1683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1697..1736
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1791..1810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1843..1874
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1886 AA; 217811 MW; FBE1B2860BFB0E55 CRC64;
MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT LRKKSKKGIF
PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS TIWRQLYVQD NREMFRSVRH
MIYDLIEWRS QILSGTLPQD ELKELKKKVT AKIDYGNRIL DLDLVVRDED GNILDPELTS
TISLFRAHEI ASKQVEERLQ EEKSQKQNID INRQAKFAAT PSLALFVNLK NVVCKIGEDA
EVLMSLYDPV ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ
IVRVGRMELR DNNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP FQPLALDDAI
RHKPLNMSSR FSPRVAGEND FLQTVINKVI AAKEVNHKGQ GLWVTLKLLP GDIHQIRKEF
PHLVDRTTAV ARKTGFPEII MPGDVRNDIY VTLVQGDFDK GSKTTAKNVE VTVSVYDEDG
KRLEHVIFPG AGDEAISEYK SVIYYQVKQP RWFETVKVAI PIEDVNRSHL RFTFRHRSSQ
DSKDKSEKIF ALAFVKLMRY DGTTLRDGEH DLIVYKAEAK KLEDAATYLS LPSTKAELEE
KGHSATGKSM QSLGSCTISK DSFQISTLVC STKLTQNVDL LGLLKWRSNT SLLQQNLRQL
MKVDGGEVVK FLQDTLDALF NIMMENSESE TFDTLVFDAL VFIIGLIADR KFQHFNPVLE
TYIKKHFSAT LAYTKLTKVL KNYVDGAEKP GVNEQLYKAM KALESIFKFI VRSRILFNQL
YENKGEADFV ESLLQLFRSI NDMMSSMSDQ TVRVKGAALK YLPTIVNDVK LVFDPKELSK
MFTEFILNVP MGLLTIQKLY CLIEIVHSDL FTQHDCREIL LPMMTDQLKY HLERQEDLEA
CCQLLSHILE VLYRKDVGPT QRHVQIIMEK LLRTVNRTVI SMGRDSELIG NFVACMTAIL
RQMEDYHYAH LIKTFGKMRT DVVDFLMETF IMFKNLIGKN VYPFDWVIMN MVQNKVFLRA
INQYADMLNK KFLDQANFEL QLWNNYFHLA VAFLTQESLQ LENFSSAKRA KILNKYGDMR
RQIGFEIRDM WYNLGQHKIK FIPEMVGPIL EMTLIPETEL RKATIPIFFD MMQCEFHSTR
SFQMFENEII TKLDHEVEGG RGDEQYKVLF DKILLEHCRK HKYLAKTGET FVKLVVRLME
RLLDYRTIMH DENKENRMSC TVNVLNFYKE IEREEMYIRY LYKLCDLHKE CDNYTEAAYT
LLLHAKLLKW SEDVCVAHLT QRDGYQATTQ GQLKEQLYQE IIHYFDKGKM WEEAIALGKE
LAEQYENEMF DYEQLSELLK KQAQFYENIV KVIRPKPDYF AVGYYGQGFP TFLRGKVFIY
RGKEYERRED FEARLLTQFP NAEKMKTTSP PGDDIKNSPG QYIQCFTVKP KLDLPPKFHR
PVSEQIVSFY RVNEVQRFEY SRPIRKGEKN PDNEFANMWI ERTIYTTAYK LPGILRWFEV
KSVFMVEISP LENAIETMQL TNDKINSMVQ QHLDDPSLPI NPLSMLLNGI VDPAVMGGFT
NYEKAFFTDR YLQEHPEAHE KIEKLKDLIA WQIPFLAEGI RIHGDKVTEA LRPFHERMEA
CFKQLKEKVE KEYGVRIMPS SLDDRRGSRP RSMVRSFTMP SSSRPLSVAS VSSLSSDSTP
SRPGSDGFAL EPLLPKKMHS RSQDKLDKDD LEKEKKDKKK EKRNSKHQEI FEKEFKPTDI
SLQQSEAVIL SETISPLRPQ RPKSQVINVI GSERRFSVSP SSPSCQQTPP PVTPRAKLSF
SMQSSLELNG MTGADVADVP PPLPLKGSVA DYGNLMENQD LLGSPTPPPP PPHQRHLPPP
LPSKTPPPPP PKTTRKQTSV DSGIVQ
//
