ID A0A2K5MEG4_CERAT Unreviewed; 841 AA.
AC A0A2K5MEG4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Prominin 1 {ECO:0000313|Ensembl:ENSCATP00000023584.1};
GN Name=PROM1 {ECO:0000313|Ensembl:ENSCATP00000023584.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000023584.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000023584.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the prominin family.
CC {ECO:0000256|ARBA:ARBA00006058}.
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DR RefSeq; XP_011900796.1; XM_012045406.1.
DR AlphaFoldDB; A0A2K5MEG4; -.
DR Ensembl; ENSCATT00000047802.1; ENSCATP00000023584.1; ENSCATG00000035341.1.
DR GeneID; 105579031; -.
DR CTD; 8842; -.
DR GeneTree; ENSGT00530000063586; -.
DR OrthoDB; 3538424at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000035341; Expressed in colon and 11 other cell types or tissues.
DR GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008795; Prominin.
DR PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR PANTHER; PTHR22730:SF3; PROMININ-1; 1.
DR Pfam; PF05478; Prominin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..841
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014457250"
FT TRANSMEM 102..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 793..813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 253..283
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 841 AA; 94516 MW; 315345674A830A76 CRC64;
MALVLGSLLL LGLCGNSFSG GQPSSTDAPK TWNYELPATN YETQDSHTAG PIGILFELVH
IFLYVVQPRD FPEDTLRKVI QKARESKIDY DKPETLILGL KIIYYEAGII LCSVLGLLFI
ILMPLVGYFF CMCRCCNKCG GELHQRQKEN GLFLRKCFAI SLLVICIIIS IGIFCGFVAN
HQVRTRIKRS RKLADSNFKD LRTLLNETPE QIKYILAQYN TTKDKAFSDL NSINSVLGGG
ILDRLRPNII PVLDEIKSMA TAIKETKEAL ENMNSTLKSL HQQSTQLSSS LTSVKTSLRA
SLNDPLCSVR PSSETCNSIR LSLSQLNSNP ELRQLPPVDA ELDKVNNVLR TDLDGLVQQG
YQSLNDIPDR VQSQTKTVIA GIKRVLNSIG SDIDNVTQHL PIQDILSEFS VYVNNTESYI
HRNLPTLEEY DSYWWLGGLV ICSLLTLIVI FYYLGLLCGV CGYDRHATPT TRGCVSNTGG
VFLMVGVGLS FLFCWILMII VVLTFVFGAN VEKLICEPYT SKELFRVLDT PYLLNEDWEY
YLSGKLFNKS EMKLTFQQVY SDCKKNRGTY GTLHLENSFD ISDYLNINEH TASISSELES
LKVNLNIFLL GAAGRKSLQD FAACGIDRMS YDTYLAQTGK SPAGVNLLSF AYDLEAKANS
LPPGNLRNSL KRDAQTIKTI HQQRVLPIEQ SLSTLYQSVK ILQRTGNGLL ERVNRILASL
DFAQNFITNN ISSVIIEETK KYRKTIIGYF EHYLQWIEFS IREKVASCKP VATALDTAVD
VFLCSYIIDP LNLFWFGIGK ATVFLLPALI FAVKLAKYYR RMDSEDVYDD VETIPMKNPS
H
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