ID A0A2K5MFD6_CERAT Unreviewed; 184 AA.
AC A0A2K5MFD6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Interleukin-7 {ECO:0000256|ARBA:ARBA00019460};
GN Name=IL7 {ECO:0000313|Ensembl:ENSCATP00000023912.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000023912.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000023912.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the IL-7/IL-9 family.
CC {ECO:0000256|ARBA:ARBA00007621}.
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DR AlphaFoldDB; A0A2K5MFD6; -.
DR SMR; A0A2K5MFD6; -.
DR STRING; 9531.ENSCATP00000023912; -.
DR Ensembl; ENSCATT00000048133.1; ENSCATP00000023912.1; ENSCATG00000035484.1.
DR GeneTree; ENSGT00390000004451; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000035484; Expressed in lymph node and 7 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:Ensembl.
DR GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR GO; GO:0045453; P:bone resorption; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:Ensembl.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0046622; P:positive regulation of organ growth; IEA:Ensembl.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0002360; P:T cell lineage commitment; IEA:Ensembl.
DR Gene3D; 1.20.1250.50; -; 1.
DR InterPro; IPR001181; IL-7.
DR InterPro; IPR038325; IL7_sf.
DR PANTHER; PTHR48404; INTERLEUKIN-7; 1.
DR PANTHER; PTHR48404:SF1; INTERLEUKIN-7; 1.
DR Pfam; PF01415; IL7; 1.
DR PIRSF; PIRSF001942; IL-7; 1.
DR PRINTS; PR00435; INTERLEUKIN7.
DR SMART; SM00127; IL7; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001942-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..184
FT /note="Interleukin-7"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014449758"
FT DISULFID 34..173
FT /evidence="ECO:0000256|PIRSR:PIRSR001942-1"
FT DISULFID 66..161
FT /evidence="ECO:0000256|PIRSR:PIRSR001942-1"
FT DISULFID 79..124
FT /evidence="ECO:0000256|PIRSR:PIRSR001942-1"
SQ SEQUENCE 184 AA; 21069 MW; A45018D67173ADB0 CRC64;
MLHSKILFHF VSFRYIFGLP PLILVLLPVA SSDCDIEGKD GKQYESVLMV SIDQLLDSMK
EIGSNCLNNE FNFFKRHLCD DNKEGMFLFR AARKLRQFLK MNSTGDFDLH LLKVSEGTTI
LLNCTGKVKG RKPAALGEPQ PTKSLEENKS LKEQKKLNDS CFLKRLLQKI KTCWNKILMG
TKEH
//
