ID A0A2K5MG32_CERAT Unreviewed; 993 AA.
AC A0A2K5MG32;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Adhesion G protein-coupled receptor G2 {ECO:0000313|Ensembl:ENSCATP00000024143.1};
GN Name=ADGRG2 {ECO:0000313|Ensembl:ENSCATP00000024143.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000024143.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000024143.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A2K5MG32; -.
DR Ensembl; ENSCATT00000048365.1; ENSCATP00000024143.1; ENSCATG00000035439.1.
DR GeneTree; ENSGT00940000156341; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000035439; Expressed in thymus and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15444; 7tmB2_GPR64; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF264; ADHESION G-PROTEIN COUPLED RECEPTOR G2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 606..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 711..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 836..858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 604..859
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 297..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 894..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 993 AA; 109302 MW; D63E4DE546B15940 CRC64;
MVFSGRQCGR VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PDVTLSLPPL
NKTEKTKITI VKTFNASGVK LQRNICNLSS ICNDSAFFRG EIMFQYDRES TIPQNQHITN
GTLTGVLSLS ELKRSELNKT LQTLSETYFI MCATAEAQST LNCTFTIKLN NTMNACAVIA
ALERVKIRPM EHCCCSVRTP CPSSPEELEK LQCDLQDPIV CLADHPRGPP FSSSQSIPVV
PRATVLSQVP NATSFAEPPD YSPVTHNVLS PIGEIHPLSP QPSAPIASSP VIDMSPQSET
ISSPMPQTHV SGTPPPVKAS FSSPTVSAPA NVITTSAPPV QTDIVNTSSI SDLENQVSQM
EKALSFGSLE PNLAGEMINQ VSKLLHSPPD MLAPLAQRLL KVVDDIGLQL NFSNKTISLT
SPSLALAVIR VNASSFNTTT FVAQDPANLQ VSLETQAPEN SIGTITLPSS LMNNLPANDM
ELASRVQFNF FETPALFQDP SLENLSLISY VISSSVANLT VRNLTRNVTV TLKHVNPSQD
ELTVRCVFWD LGRNGGRGGW SDDGCSVKDR RLNETICTCS HLTSFGILLD LSRTSVLPAQ
TMALTFITYI GCGLSSIFLS VTLVTYVAFE KIRRDYPSKI LIQLCAALLL LNLVFLLDSW
IALYKMQGVC ISVAVFLHYF LLVSFTWMGL EAFHMYLALV KVFNTYIRKY ILKFCIVGWG
VPALVVTIIL TISPDNYGLG SYGKFPNGSP DDFCWINNNA VFYITVVGYF CVIFLLNVSM
FIVVLVQLCR IKKKKQLGAQ RKTSIQDLRS IAGLTFLLGI TWGFAFFAWG PVNVTFMYLF
AIFNTLQGFF IFIFYCVAKE NVRKQWRRYL CCGKLRLAEN SDWSKTATNG LKKQTVNQGV
SSSSNSLQSN SNSTNSTTLL VNNDCSVHAS RNGNASTERN GVSFSVQNGD VCLHDFTGKQ
HMFNEKEDSC NGKGRMALRR TSKRGSLHFI EQM
//
