ID A0A2K5MHW4_CERAT Unreviewed; 252 AA.
AC A0A2K5MHW4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Major histocompatibility complex, class II, DO alpha {ECO:0000313|Ensembl:ENSCATP00000024807.1};
GN Name=HLA-DOA {ECO:0000313|Ensembl:ENSCATP00000024807.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000024807.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000024807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MHC class II family.
CC {ECO:0000256|RuleBase:RU004238}.
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DR RefSeq; XP_011891789.1; XM_012036399.1.
DR AlphaFoldDB; A0A2K5MHW4; -.
DR Ensembl; ENSCATT00000049034.1; ENSCATP00000024807.1; ENSCATG00000035917.1.
DR GeneID; 105575002; -.
DR GeneTree; ENSGT00940000162112; -.
DR OMA; QFAHEFD; -.
DR OrthoDB; 4118190at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000035917; Expressed in lymph node and 2 other cell types or tissues.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR CDD; cd21004; IgC1_MHC_II_alpha_HLA_DO; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR PANTHER; PTHR19944:SF44; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC II {ECO:0000256|ARBA:ARBA00023182};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..252
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014457254"
FT TRANSMEM 224..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 115..195
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 252 AA; 27788 MW; 571A2F180FB647A8 CRC64;
MALRAGLILG FHTLMTLLSP QEAGATKDTA DHMGSYGPAF YQSYGASGQF THEFDGEQLF
SVDLKKSEAV WRLPEFGDFA RFDPQGGLAG IAAIKAHLDV LVERSNRTRA INVPPRVTVF
PKSRVELGQP NILICVVNNI FPPVINITWL RNGQAVTEGV AQTSFYSQPD HLFRKFHYLP
FMPSAEDVYD CQVEHWGLDA PLLRHWEHQV PIPPPDAMET LVCALGLAIG LVGFLVGTIL
IIMGTYVSSA PR
//
