ID A0A2K5MIY4_CERAT Unreviewed; 814 AA.
AC A0A2K5MIY4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=G protein-coupled receptor 156 {ECO:0000313|Ensembl:ENSCATP00000025171.1};
GN Name=GPR156 {ECO:0000313|Ensembl:ENSCATP00000025171.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000025171.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000025171.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR RefSeq; XP_011923839.1; XM_012068449.1.
DR RefSeq; XP_011923840.1; XM_012068450.1.
DR RefSeq; XP_011923841.1; XM_012068451.1.
DR RefSeq; XP_011923842.1; XM_012068452.1.
DR AlphaFoldDB; A0A2K5MIY4; -.
DR STRING; 9531.ENSCATP00000025171; -.
DR Ensembl; ENSCATT00000049401.1; ENSCATP00000025171.1; ENSCATG00000036077.1.
DR GeneID; 105589743; -.
DR KEGG; caty:105589743; -.
DR CTD; 165829; -.
DR GeneTree; ENSGT00940000159755; -.
DR OMA; THFCASQ; -.
DR OrthoDB; 5396723at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000036077; Expressed in adult mammalian kidney.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15292; 7tmC_GPR156; 1.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR041946; GPR156_7TM.
DR PANTHER; PTHR10519:SF63; G-PROTEIN COUPLED RECEPTOR 156-RELATED; 1.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PRINTS; PR01176; GABABRECEPTR.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..312
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 422..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 355..389
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 436..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 814 AA; 88900 MW; 40A2C325962A88B0 CRC64;
MEPEINCSEL CDGFPGQELD RRPLHDLCKT TITSSHHSSK TISSLSPVLL GIVWTFLSCG
LLLILFFLAF TIRCRKNRIV KMSSPNLNIV TLLGSCLTYS SAYLFGIQDV LVGSSMETLI
QIRLSMLCIG TSLVFGPILG KSWRLYKVFT QRVPDKRVII KDLQLLGLVA ALLMADVILL
VTWVLTDPIQ CLQILSVSMT VTGREVSCTL TSTHFCASQY SDVWIALVWG CKGLLLLCGA
YLAGLTGHVS SPPVNQSLTI MVGVNLLVLA AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
TTINCFIFIP QLKQWKAFEE ENQTIRRMAK YFSTPSKNFH TQYGEEENCH LKGGKSSMER
LLTEKNAVIE SLQEQVNNAK EKLVRLMSAE CTYDLPEQAA PPASSPSKDV QAAASVHTLA
AAQGPSGHLS DFRNDPGMAT QDSQCTSGPS SHAQSLEGPG KDTSLSPGKE KKISDSKDFS
DHLDSGCSQK PWTEQSLGPE RGDQVPMAPS QSLLPGRGGS DPQRQRHLEN SEEPQERRSQ
VSSVIREKLQ EVLQDLGLGP EASLPTTPSC HQQTWKNSAA FSPQKMPLSK ELGFSPYMVR
RRRATQQARS HFPGSASSSV GHRANRTVSG AHSRLHVQNG DSPSLAPQTA DCRTRRPSSR
KPSLPSDPQD RRGTLERSRQ SQTEPEGARG SEAAFLPQPS GSGLAPSPAA PCLSKASPDL
PEQWHLWPPV PSGCPSLSSQ HSCFDTESSS SDEFFCHCHR PYCEICFQSS SDSSDSGTSD
TDPEPTAGLA SWEKLWARSK PIVNFKDDLK PTLV
//
