ID A0A2K5MJU7_CERAT Unreviewed; 676 AA.
AC A0A2K5MJU7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=PML-RARA regulated adaptor molecule 1 {ECO:0000313|Ensembl:ENSCATP00000025487.1};
GN Name=PRAM1 {ECO:0000313|Ensembl:ENSCATP00000025487.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000025487.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000025487.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5MJU7; -.
DR STRING; 9531.ENSCATP00000025487; -.
DR Ensembl; ENSCATT00000049717.1; ENSCATP00000025487.1; ENSCATG00000036215.1.
DR GeneTree; ENSGT00530000063460; -.
DR OMA; HTRMMID; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000036215; Expressed in bone marrow and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0043313; P:regulation of neutrophil degranulation; IEA:Ensembl.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR043443; FYB1/2-like.
DR InterPro; IPR029294; hSH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR16830:SF11; PML-RARA-REGULATED ADAPTER MOLECULE 1; 1.
DR PANTHER; PTHR16830; SH2 CONTAINING ADAPTOR PRAM-1 RELATED; 1.
DR Pfam; PF14603; hSH3; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 577..655
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..86
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..464
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 75300 MW; 07777EBF5F0C7E74 CRC64;
VAHHLPAAME SHQDFRSIKA KFQASQPEPS DLPKKLPKPE FSKLKKFPQP ELSEHLKKPP
PPEVTDLPKK PPPPEFTDLP KKPPPPEFTD LPKKLRPPEF TDLPKKPRPP PPEFTDLPKK
PSKLEFSDVS KKFPQLEATP FPRKPPQPEV GEAPVKASLR EPNTPVRKPQ QSDELSHPPA
QPEVNILPKT SLPQPESSDS LPHSPKPNFS SIPKKAVQPE FIVHPRKPPQ PQADGLPKKC
VPQPEFSEAA QTPLWKPQSG EPKHDSSAFP KKASQPPLSD FPKKPPQPEL GDLTRTSSEP
EVSVLPKRPR PAEFKALSKK PPQPELGGLP RTSSEPEFNS LPRKLLQPDR RGPPRKFSQP
EPNAVLKRHL QPEFFGDLPR KPLLPSSASE SSLPAAVAGS SSRHPLSPGF GVAGTPRWRS
GGLVHSGGAR PGLRPSHPPR RRPLPAASSL GPPPAKPPLP PGPVDMQSFR RRSAASTDLR
RTRSAAALHF QARQPEDIPP IPDEIYELYD DVEPRDDSSP SPKGRDEAPS VQQVTRRPPQ
DSALRYHGQR GREKDPQPQQ LPPMDPKLQK QLRKAEKAER EFRKKFKFEG EIVVHTKMMI
DPNAKTRRGG GKHLGIRRGE ILEVIEFTSN EEMLCRDPKG KYGYVPRIAL LPLETEVYDD
VDFCDPLENQ PLPLGR
//
