ID   A0A2K5MKE0_CERAT        Unreviewed;       358 AA.
AC   A0A2K5MKE0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Glyoxylate and hydroxypyruvate reductase {ECO:0000313|Ensembl:ENSCATP00000025580.1};
GN   Name=GRHPR {ECO:0000313|Ensembl:ENSCATP00000025580.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000025580.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000025580.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR   AlphaFoldDB; A0A2K5MKE0; -.
DR   STRING; 9531.ENSCATP00000025580; -.
DR   Ensembl; ENSCATT00000049811.1; ENSCATP00000025580.1; ENSCATG00000036253.1.
DR   GeneTree; ENSGT00940000158578; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000036253; Expressed in liver and 12 other cell types or tissues.
DR   GO; GO:1902494; C:catalytic complex; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0008465; F:glycerate dehydrogenase activity; IEA:Ensembl.
DR   GO; GO:0030267; F:glyoxylate reductase (NADP+) activity; IEA:Ensembl.
DR   GO; GO:0016618; F:hydroxypyruvate reductase activity; IEA:Ensembl.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0070402; F:NADPH binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0046487; P:glyoxylate metabolic process; IEA:Ensembl.
DR   CDD; cd05301; GDH; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR10996:SF137; GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003719};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT   DOMAIN          9..116
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          117..288
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   358 AA;  38658 MW;  99C4D96AB8B99AC2 CRC64;
     MRPVLLMKVF VTRRIPPEGR AALAQAADCE VEQWDSDEPI PVKELARGVA GAHGLLCLLS
     DRVDKRILDA AGANLKVIST LSVGVDHLAL DEIKKRGIRV GYTPDVLTDA TAELAVSLLL
     TTCRRLPEAI EEVKNGGWTS WKPLWLCGYG LTQSTVGIVG LGRIGQAIAR RLKPFGVQRF
     LYTGRQPRPE EAAEFQAEFV STPELAAQSD FIVVACSLTP ATKGLCNKDF FQKMKETAVF
     VNISRGDVVN QDDLYQALAS GQIAAAGLDV TTPEPLPTNH PLLTLKNCGP GIQLRAPGLL
     QKTVLGLRRG RSGHEAAVAA AGSAKSKHWA AAMSYCRQEG KDPIICDEKR PCSSKQRS
//