ID A0A2K5MKF5_CERAT Unreviewed; 760 AA.
AC A0A2K5MKF5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Semaphorin 4A {ECO:0000313|Ensembl:ENSCATP00000025595.1};
GN Name=SEMA4A {ECO:0000313|Ensembl:ENSCATP00000025595.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000025595.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000025595.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011934041.1; XM_012078651.1.
DR RefSeq; XP_011934042.1; XM_012078652.1.
DR RefSeq; XP_011934043.1; XM_012078653.1.
DR RefSeq; XP_011934044.1; XM_012078654.1.
DR RefSeq; XP_011934045.1; XM_012078655.1.
DR RefSeq; XP_011934046.1; XM_012078656.1.
DR AlphaFoldDB; A0A2K5MKF5; -.
DR STRING; 9531.ENSCATP00000025595; -.
DR Ensembl; ENSCATT00000049826.1; ENSCATP00000025595.1; ENSCATG00000036260.1.
DR GeneID; 105594505; -.
DR KEGG; caty:105594505; -.
DR CTD; 64218; -.
DR GeneTree; ENSGT00940000161509; -.
DR OMA; KNNETQC; -.
DR OrthoDB; 4266123at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000036260; Expressed in lung and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:1904891; P:positive regulation of excitatory synapse assembly; IEA:Ensembl.
DR GO; GO:1905704; P:positive regulation of inhibitory synapse assembly; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0010594; P:regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IEA:Ensembl.
DR GO; GO:0045063; P:T-helper 1 cell differentiation; IEA:Ensembl.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF15; SEMAPHORIN-4A; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00352};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..760
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014431983"
FT TRANSMEM 680..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..494
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 721..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 113..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00352"
FT DISULFID 142..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00352"
FT DISULFID 269..379
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00352"
FT DISULFID 293..339
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00352"
SQ SEQUENCE 760 AA; 83309 MW; E6C74B6D532A594F CRC64;
MALPALGLDP WSLLGLFLFQ LLQLLLPTTT AGGGGQGPMP RVRYYAGDER RALSFFHQKG
LQDFDTLLLS GNGNTLYVGA REAILALDIQ DPGVPKLKNM IPWPASDRKK SECAFKKKSN
ETQCFNFIRV LVSYNVTHLY TCGTFAFSPA CTFIELQDSH LLPILKDKVM EGKGQSPFDP
AHKHTAVLVD GMLYSGTMNN FLGSEPILMR TLGSQPVLKT DNFLRWLHPD ASFVAAIPST
QVVYFFFEET ASEFDFFERL HTSRVARVCK NDVGGEKLLQ RKWTTFLKAQ LLCTKPGQLP
FNVIRHAVLL PADSPTAPHI YAVFTSQWQI GGTRSSAVCA FSLLDIERVF KGKYKELNKE
TSRWTTYRGP ETNPRPGSCS VGPSSDKALT FMKDHFLMDE QVVGTPLLVK SGVEYTRLAV
ETAQGLDGHS HLVMYLGTTT GSLHKAVVSG DSGAHLVEEI QLFPDPEPVR NLQLAPTQGA
VFVGFSGGVW RVPRANCSVY ESCVDCVLAR DPHCAWDPES RTCCFLSAPT LNSWKQDMER
GNPEWACASG PMSRSLRPQS RPQIIKEVLA VPNSFLELPC PHLSALASYY WSHGPAAVPE
ASSTVYNGSL LLIVQDGVGG LYQCWATENG FSYPVVSYWV DSQDQSLALD PELAGIPREH
VEVPLTRVSG GTALAAQRSY WPHFVTVTVL LALVLSGALI ILLASPLGAL RARGKVQGCE
TLPPGEKAPL SREQHLQSPK ECRTSASDVD ADNCLGTEVA
//
