ID A0A2K5MLT3_CERAT Unreviewed; 2908 AA.
AC A0A2K5MLT3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Otogelin {ECO:0000313|Ensembl:ENSCATP00000026187.1};
GN Name=OTOG {ECO:0000313|Ensembl:ENSCATP00000026187.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000026187.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000026187.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 9531.ENSCATP00000026187; -.
DR Ensembl; ENSCATT00000050423.1; ENSCATP00000026187.1; ENSCATG00000036498.1.
DR GeneTree; ENSGT00940000157490; -.
DR Proteomes; UP000233060; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:Ensembl.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd19941; TIL; 4.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR007934; AbfB_ABD.
DR InterPro; IPR036195; AbfB_ABD_sf.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF228; OTOGELIN; 1.
DR Pfam; PF05270; AbfB; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF01826; TIL; 1.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00215; VWC_out; 3.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF110221; AbfB domain; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 4.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51233; VWFD; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2908
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014457260"
FT DOMAIN 102..139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 150..322
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 512..688
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 984..1152
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2088..2272
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2823..2908
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 316..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1478..1546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1640..1681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1695..1787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1480..1507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1645..1681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1695..1731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1762..1787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2837..2886
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 2908 AA; 312616 MW; 0D4ABDF2ED15C61E CRC64;
MGVLASVLCW LLCVWLPWGE PAAESLRVQR LGERVVDSGR LGARGMRNVK GMRNGPGQIC
FASSSSHQKV TLAMGDTVTV MGGQQAEAPD SVAMSSWERR LHRAKCAPSY LFSCFNGGEC
VHLAFCDCRR FNATGPRCQM VYNAGPERDS ICRAWGQHHV ETFDGLYYYL SGKGSYTLVG
LHEPEGQSFS IQVHNDPQCG SSPYACSKAV SLFFAGEQEI HLAKEVTHGG ARVQLPHVMG
SVRLQRLAGY VIVRHQSAFT LAWDGASAVY IKMSPEFLGW THGLCGNNNA DPQDDLVTSY
GKLTDDVVEF VHSWQEQAPN QPPGPTTSSL PRPPCLQQNP GTMQGVYEQC EALLRPPFDA
CHAYVSPLPF TASCTSDLCQ SMGDEATWCR ALAEYARACA QAGRPLQGWR TQLRQCTVHC
KEKAFTYNEC IACCPASCQP RASCVDSEIA CVDGCYCPNG LIFEDGGCVA PAECPCEFHG
TLYPPGSVVK EDCNACTCTA GKWECSTAVC PAECSVTGDI HFTTFDGRRY TFPATCQYIL
AKSRSSGTFT VTLQNAPCGL NQDGACVQSV SVILHQDPRR QVTLTQAGDI LLFDQYKIIP
PYTDDAFEIR RLSSVFLRVR TNVGVRVLYD REGLRLYLQV DQRWVEDTVG LCGTFNGNTQ
DDFLSPVGVP ESTPQLFGNS WKTLSACSPL IPGSPLDPCD VHLQAASYSV QACSVLTGEL
FAPCSAFLSP VPYFEQCRRD ACRCGQPCLC ATLAHYAHLC RRHGLPVDFR ARLPACALSC
EATKEYSPCV ALCGQTCQDL ASPEACGIDG GDDLSRDECV EGCACPPDTY LDTQADLCVP
RNQCSCHFQG VDYSPGDSDI PSLGHCHCKD GVMSCDSRAP AAACPAGQVF VNCSDLHTDL
ELSRERTCEQ QLLNLSVSAR GPCLSGCACP HGLLRHGDAC FLPEECPCTW KGKEYFPGDQ
VMSPCHTCVC QRGSFQCTLH PCASTCTAYG DRHYRTFDGL PFDFVGACKV HLVKSMSDVS
FSVIVENVNC YSSGMICRKF ISINVGSSLI VFDDDSGNPS PESFLDDKQE VHTWRVGFFT
LVHFPREHIT LLWDQRTTVH IQAGPQWQGQ LAGLCGNFDL KTINEMRTPE NLELTNPQEF
GSSWVAVECP DTLDPRDTCV LNPLREPFAK KECSILLSEV FEICHPVVDV TWFYSNCLTD
TCGCSQGGDC ECFCASVSAY AHQCCQHGVA VDWRTPRLCR ECCSRGLFSP VLGKGPYQLS
SLAAGGALVA MKAVGEDIVL VRTKDVAPGD IVSFLLTAAL YKAKAHDPDI VSLEAADRPN
FFLHVTANGS LELAKWQGRD AFQQHASFLL HRGTWQAGLV ALESLAKPSS FLCASGPVLA
LRLYEHTEVF RRGTLFRLLD AKPSGPAYPV CEWHYDACAS SCFQTCRDPW AASCRDVPRV
EGCVPVCPAP KVLDEVTQRC VYLEDCVEPA VWVPTEALGN ETLPPSQGLP TPSDEEPQLS
QESLGSPTHR PALAPAAPLP TALNPPVAAT EEPVVSPGPT QSTLQQPLGL TASQLPARPT
EAPASKGVTA SLLAVPHTPE SSSLPVALQT PTPGTVSGAV ETTRVTVIFA GSPNITVSSR
SPPAPRFPLM TKAVTVRGHG SLPVRTTPLQ PSLTASPSSR PVASPGAISR SPTSSGSHKA
VLTPAVTKVI SRTGVPQPTQ AQSASSPSTP LTVARTAAEQ VPVSPLTTRS AEMVLPTEKG
EAGHSQPMGS PASPQPHPLS TAPPRTAQHT TTATRSPALP PETPTAASLS TAAHGLGATP
FVSLESTGPS QFLSGLPPDT SLPLAKVGTS APVATPGPKA SVITTPLQSQ AMTLPAQTLS
PAPPFTPAAM TQAYPPAHIA PSAAGIAPGL LLGATLPTSG VLPVTEGMAS TVSVVSRKST
TGKVAILSQQ VSLPTSIYGS AQGGPTELMP ATSHPLTPLV TEPEGAQAGT ALPVPTSYPL
SPVSARTAPQ DSTLVLLPQL AEAHGTSAGA YLAAEPVDEA ITEPSGRSAP ALSIVEGLAE
ALATTTEANT STTCVPIAEQ DCVRHICLEG QLIRVNQSQH CPQGAAPPRC GILGLAVRVG
GDRCCPLWEC AWPVSIFPDL DHVLSVKDPD EMVTSCTGLQ SGHLNWPPFC LVMLNVTHLA
HQVTIDRFNR KVTVDLQPVW PPVSRYGFRI EDTGHMYMIL TPSHIQIQWL HSSGLMIMEA
SKASKAQGHG LCGICDGDAA NDLTLKDGSV VGGAEDPAPF LDSWQVPSSL TAVGQTRFRP
DSCATTDCSP CLRMVSNRTF SACHRFVPPE SFCELWIRDT KYVQQPCVAL TVYVAMCHKF
HVCIEWRRSD YCPFLCSSDS TYQACVTACE PPKTCQDGIL GPLDPERCQV LGEGCVCSEG
TILHRRHSAL CIPEAKCACT DSMGVPRALG ETWNSSLSGC CQHQCQAPDT IIPVDLGCPD
PRPESCPRFG EVALLLPTKD PCCLRTVCVC NQTLCEGLAP TCHPGHRLLT HFQEDSCCPS
YSCECDPDLC EAELVPSCRQ DQTLIVGRLG DSCCTSYFCA CGDCPDPIPE CQEGEALTVH
RNTTELCCPL YQCVCESFRC PQVQCGPGTA LVEVWSPDRC CPYKSCECDC DTIPVPRCHL
WEKSQLDEEF MHSVDNVCGC AKYECVKAPV CLSHELGVMQ PGQTVVELSA DGVCHTSRCT
AVLDPLTSFY QINTTSVLCD IHCEANQEYQ HPRDLAACCG SCRNVSCLFT FPNGTTSLFL
PGASWIADCT RHHCSSTPLG AVLVRSPISC PPLNETECAK VGGSVVPSLE GCCRTCKEDG
RSCKKVTIRM TIRKNECRSH TPVNLVSCDG RCPSASIYNY NINTYARFCK CCREVGLQRR
SVQLFCATNA TWVPYTVQEP TDCACQWS
//
