ID A0A2K5MLX7_CERAT Unreviewed; 839 AA.
AC A0A2K5MLX7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Transmembrane protein 245 {ECO:0000313|Ensembl:ENSCATP00000026232.1};
GN Name=TMEM245 {ECO:0000313|Ensembl:ENSCATP00000026232.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000026232.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000026232.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC family. {ECO:0000256|ARBA:ARBA00009773}.
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DR AlphaFoldDB; A0A2K5MLX7; -.
DR Ensembl; ENSCATT00000050468.1; ENSCATP00000026232.1; ENSCATG00000036531.1.
DR GeneTree; ENSGT00390000001667; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000036531; Expressed in bone marrow and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR002549; AI-2E-like.
DR PANTHER; PTHR21716; TRANSMEMBRANE PROTEIN; 1.
DR PANTHER; PTHR21716:SF4; TRANSMEMBRANE PROTEIN 245; 1.
DR Pfam; PF01594; AI-2E_transport; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 839 AA; 92506 MW; 3A532B58D20E7D37 CRC64;
MADGGGATAA PSPRGSPGPA PRVPRAVGPS GGGGETPRTA PLALRFDKPI KQAFYNTGAV
LFVCLCCGAA VLVYFILEAF LRPLLWAVLC GTFLHPFKSS LTRLGRHWLQ RLHRAHTPIV
LAALLLPLCF IDYGVEALGE QALRRRRLLL LLGAGGPLLY GLYCLGSYLG VQVLLLHAAA
LICRGLDYFS SLWIWTLVVG YVLTVSFKWN ASTERYLRAV SIPIWIILLF HLASLAGSWR
IPVFLVIVFL MSVGTLYEKQ NGKESSGAEL PGQVISMAAS TLANLAISIT GYESSSEDQL
STQPAEALDR GESPPTLSTS PSPSSPSPTS PSPTLGRRRP EIGTFLRKKK TSDIYFVSLV
WAIVVVQIWL NLWIVQLLPV PIAVWILKKL VIHFGVVDFL EKHYHVWWGV TESFLKERQG
ALAPWPIVGL GKFLLKVDSK VLYFKDLDSF LSVSVIQVHQ ESVHMIEVTS NLINETLANH
PEWANWLPEA QVVQRALNSA ANNVYQYGRE WITHKLHKIL GDKVNNTAVI EKQVLELWDR
LYHSWFVKNV THSGRHKGQK LHVSRQNSWL GDILDWQDIA SFVHENIETF LSILESLWIV
MSRNVSLLFT TVTTLLTILF YSGTALLNFV LSLIIFLTTL FYLLSSSDEY YKPVKWVISL
TPLSQPGPSS NIIGQSVEEA IRGVFDASLK MAGFYGLYTW LTHTIFGINI VFIPSALAAI
LGAVPFLGTY WAAVPAVLDL WLTQGLGCKA ILLLIFHLLP TYFVDTAIYS DISGGGHPYL
TGLAVAGGAY YLGLEGAIIG PILLCILVVA SNIYSAMLVS PTNSVPTPNQ TPWPAQTQR
//
