ID   A0A2K5MLZ6_CERAT        Unreviewed;       879 AA.
AC   A0A2K5MLZ6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Transmembrane protein 245 {ECO:0000313|Ensembl:ENSCATP00000026229.1};
GN   Name=TMEM245 {ECO:0000313|Ensembl:ENSCATP00000026229.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000026229.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000026229.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC       family. {ECO:0000256|ARBA:ARBA00009773}.
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DR   AlphaFoldDB; A0A2K5MLZ6; -.
DR   STRING; 9531.ENSCATP00000026229; -.
DR   Ensembl; ENSCATT00000050465.1; ENSCATP00000026229.1; ENSCATG00000036531.1.
DR   GeneTree; ENSGT00390000001667; -.
DR   OMA; CVHFFWK; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000036531; Expressed in bone marrow and 12 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002549; AI-2E-like.
DR   PANTHER; PTHR21716; TRANSMEMBRANE PROTEIN; 1.
DR   PANTHER; PTHR21716:SF4; TRANSMEMBRANE PROTEIN 245; 1.
DR   Pfam; PF01594; AI-2E_transport; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        53..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        147..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        216..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        239..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        354..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        460..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        631..647
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        653..671
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        815..836
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          295..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   879 AA;  97189 MW;  A65DB48E8B5C3D99 CRC64;
     MADGGGATAA PSPRGSPGPA PRVPRAVGPS GGGGETPRTA PLALRFDKPI KQAFYNTGAV
     LFVCLCCGAA VLVYFILEAF LRPLLWAVLC GTFLHPFKSS LTRLGRHWLQ RLHRAHTPIV
     LAALLLPLCF IDYGVEALGE QALRRRRLLL LLGAGGPLLY GLYCLGSYLG VQVLLLHAAA
     LICRGLDYFS SLWIWTLVVG YVLTVSFKWN ASTERYLRAV SIPIWIILLF HLASLAGSWR
     IPVFLVIVFL MSVGTLYEKQ NGKESSGAEL PGQVISMAAS TLANLAISIT GYESSSEDQL
     STQPAEALDR GESPPTLSTS PSPSSPSPTS PSPTLGRRRP EIGTFLRKKK TSDIYFVSLV
     WAIVVVQIWL NLWIVQLLPV PIAVWILKKL VIHFGVVDFL EKHYHVWWGV TESFLKERQG
     ALAPWPIVGL GKFLLKVDSK LWHWLNKKMI IWLEKMLDKI ISIFIIFLLV IGTLLLALLL
     TAKVHQESVH MIEVTSNLIN ETLANHPEWA NWLPEAQVVQ RALNSAANNV YQYGREWITH
     KLHKILGDKV NNTAVIEKQV LELWDRLYHS WFVKNVTHSG RHKGQKLHVS RQNSWLGDIL
     DWQDIASFVH ENIETFLSIL ESLWIVMSRN VSLLFTTVTT LLTILFYSGT ALLNFVLSLI
     IFLTTLFYLL SSSDEYYKPV KWVISLTPLS QPGPSSNIIG QSVEEAIRGV FDASLKMAGF
     YGLYTWLTHT IFGINIVFIP SALAAILGAV PFLGTYWAAV PAVLDLWLTQ GLGCKAILLL
     IFHLLPTYFV DTAIYSDISG GGHPYLTGLA VAGGAYYLGL EGAIIGPILL CILVVASNIY
     SAMLVSPTNS VPTPNQTPWP AQTQRTFRDI SEDLKSSVG
//