ID   A0A2K5MMK7_CERAT        Unreviewed;      1181 AA.
AC   A0A2K5MMK7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Synapse defective Rho GTPase homolog 2 {ECO:0000313|Ensembl:ENSCATP00000026441.1};
GN   Name=SYDE2 {ECO:0000313|Ensembl:ENSCATP00000026441.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000026441.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000026441.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5MMK7; -.
DR   Ensembl; ENSCATT00000050679.1; ENSCATP00000026441.1; ENSCATG00000036631.1.
DR   GeneTree; ENSGT01030000234635; -.
DR   OMA; PMLKSPF; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000036631; Expressed in heart and 9 other cell types or tissues.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR   PANTHER; PTHR46150:SF1; RHO GTPASE-ACTIVATING PROTEIN SYDE2; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT   DOMAIN          659..778
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          815..1030
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          1..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1039..1084
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1097..1181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1039..1068
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1069..1084
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1125..1139
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1140..1154
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1155..1181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1181 AA;  132547 MW;  A148D90D5F209294 CRC64;
     MHDLPPDSGA RRGGGGLADQ GFPAGARAPG QPPSRGAADR RACPRDGERR GGGRPRQQVS
     PPRSPQRESG GGQLRTPRMR LSCSRSLESL RVGAKPLPFQ RWPSDSWIRC GGHGDWDEPP
     PRGGRMDGWS GDRARAAAPT GLQPPGSKDH GCSSGSPFRD PAGSSVIRSG KGDRQEGPSF
     LKPPAVTVKK LQKWMYKGRL LSLGMKGRTR GTAPKVTGTQ AASPNVGALK VRENSVLSVP
     PDQRITLTDL FENAYGSSMK RRELEDLKDN IEFRGHKPLN SITVSKKRNW LYQSTLRSLN
     LEEENKKCQD RSHLSISPVS LPKHQLSQSF LKSSKEYCTY VVCNATNSSL SKNCALDFNE
     ENDADDEGEI WYNPIPEDDD LGMSSALRFG EVDSAVLKLP AVNLSMLSGS DLMKAEQHTE
     DSLCSSEHTG DIQSTWSNGM NPMDPARSTE FVQQYKQRLG HKTQEGIMVE DSPMLKSFAG
     SGILAATNST ELGIIEPSSP NPSPVKKGSS INWSLPDKIK SPRTVRKLSM KMKKLPEFSR
     KLSVKGTLNY INSPDNTPSL SKYNCREIHH TDVLPSGNTT TAAKRNVISR YHLDTSVSSQ
     HNYQKKNSMS SKYSCKGGYL SDGDSPELIT KASKRGSENK FGRGKEIISN SCSKNEIDID
     AFRHYSFSDQ PKCSQYISGL MSVHFYGAED LKPPRIDSKD VFCAIQVDSV NKARTALLTC
     RTTFLDMDHT FNIEIENAQH LKLVVFSWEP TPRKNRVCCH GTVVLPALFR VTKTHQLAVK
     LEPRGLIYVK VTLMEQWENS LHGLDINQEP IIFGVDIQKV VEKENIGLMV PLLIQKCIME
     IEKRGCQVVG LYRLCGSAAV KKELREAFER DSKAVGLCEN LYPDINVITG VLKDYLRELP
     SPLITKQLYE AVLGAMAKSP LKMSSNGCEN DPTDSKYTVD LLDCLPEIEK ATLKMLLDHL
     KLVASYHEVN KMTCQNLAVC FGPVLLSQKQ EPSSHNNRVF TDSEELASAL DFKKHIEVLH
     YLLQLCLTVK KKKKNLFPEQ KKKKNYLRQK KKKTHMLNLK KKNSSGVLKK KKNRLDSQKK
     KSYENYFLKK KKNLSDVEKK KIPSEDRKKK KNYSKMKKKK VMIEQQKKKT KECTLKKKKT
     MQTIKKKKDR KNNQKKKKES IDTKKKNLER ELKKKKLNMS F
//