ID A0A2K5MMU4_CERAT Unreviewed; 275 AA.
AC A0A2K5MMU4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Chimerin 1 {ECO:0000313|Ensembl:ENSCATP00000026553.1};
GN Name=CHN1 {ECO:0000313|Ensembl:ENSCATP00000026553.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000026553.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000026553.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5MMU4; -.
DR Ensembl; ENSCATT00000050791.1; ENSCATP00000026553.1; ENSCATG00000036640.1.
DR GeneTree; ENSGT01030000234635; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000036640; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04372; RhoGAP_chimaerin; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037860; RhoGAP_chimaerin.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR PANTHER; PTHR46075:SF1; N-CHIMAERIN; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..275
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014421712"
FT DOMAIN 26..71
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 84..275
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 275 AA; 31412 MW; 72142383EC6A33C8 CRC64;
MATMGLLMLL TLAASLHFLS IRFHHVHTFR GPHWCEYCAN FMWGLIAQGV KCADCGLNVH
KQCSKMVPND CKPDLKHVKK VYSCDLTTLV KAHTTKRPMV VDMCIREIES RGLNSEGLYR
VSGFSDLIED VKMAFDRDGE KADISVNMYE DINIITGALK LYFRDLPIPL ITYDAYPKFI
ESAKIMDPDE QLETLHEALK LLPPAHCETL RYLMAHLKRV TLHEKENLMN AENLGIVFGP
TLMRSPELDA MAALNDIRYQ RLVVELLIKN EDILF
//
