ID A0A2K5MQQ1_CERAT Unreviewed; 1406 AA.
AC A0A2K5MQQ1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Rho GTPase activating protein 21 {ECO:0000313|Ensembl:ENSCATP00000027562.1};
GN Name=ARHGAP21 {ECO:0000313|Ensembl:ENSCATP00000027562.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000027562.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000027562.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}.
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DR Ensembl; ENSCATT00000051808.1; ENSCATP00000027562.1; ENSCATG00000037108.1.
DR GeneTree; ENSGT00940000155406; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000037108; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 49..158
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 595..787
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1155..1209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..814
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..848
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1084
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1406 AA; 156055 MW; EA9178219B0BF148 CRC64;
MATRRTGLPE GDGDKLKACE VSKNKDGKEQ SETVSLSEDE TFSWPGPKTV MLKRTSQGFG
FTLRHFIVYP PESAIQFSYK DEENGNRGGK QRNRLEPMDT IFVKQVKQGG PAFEAGLCTG
DRIIKVNGES VIGKTYSQVI ALIQNSDTTL ELSVMPKDED ILQVAYSQDA YLKGNEAYSG
NARNIPEPPP ICYPWLPSAP SAVAQPVEIS PPDSSLSKQQ TSTPVLTQPG RAYRMEIQVP
PSPTDVAKSN TAVCVCNESV RTVIVPSEKV VDLLSNRNNH AGPSHRTEEV RYGVNEQTSL
KTVSRTTSPP LSIPTTHLIH QTAGSRSLEP SGILLKSGNY SGHSDGISSS RSQAVEAPSV
SVNHYSPNSH QHIDWKNYKT YKEYIDNRRL HIGCRTIQER LDSLRAASQS TTDYNQVVPN
RTTLQGRRRS TSHDRVPQSV QIRQRSVSQE RLEDSVLMKY CPRSASQGAL TSPSVSFSNH
RTRSWDYIEG QDETLENVSS GTPIPDSNGE KKQTYKWSGF TEQDDRRGIY ERPRQQEIHK
SFRGPNFTVA PSVVNSDNRR LSGRGVGSVS QFSSIPSIMR KTFEKKPTAT GTFGVRLDDC
PPAHTNRYIP LIVDICCKLV EERGLEYTGI YRVPGNNAAI SSMQEELNKG MADIDVQDDK
WRDLNVISSL LKSFFRKLPE PLFTNDKYAD FIEANRKEDP LDRLKTLKRL IHDLPEHHYE
TLKFLSAHLK TVAENSEKNK MEPRNLAIVF GPTLVRTSED NMTHMVTHMP DQYKIVETLI
QHHDWFFTEE GADEPLTTVQ EESTVDSQPV PNIDHLLTNI GRTGVSPGDV SDSATSDSTK
SKGSWGSGKD QYSRELLVSS IFAAASRKRK KPKEKAQPSS SEDELDNVFF KKENVEQCHN
DTKEESKKES ETLGRKQKII IAKDNSTRKD PSMTKDEKIS LGKESTPSEE PSPPHNSKHN
KSPTLSCRFA ILKESPRSLL AQKSSHLEET GSDSGTLLST SSQASLARFS MKKSTSPETK
HSEFLANIST ITSDYSTTSS ATYLTSLDSS RLSPEVQSVA ESKGDEADDE RSELISEGRP
VETDSESEFP VFPTALTSER LFRGKLQEVT KNSRRNSEGS EVSCTEGSLT SSLDSRRQLF
SSHKLIECDT LSRKKSARFK SDSGSLGDAK NEKEAPSLTK VFDVMKKGKS TGSLLTPTRG
ESEKQEPTWK TKIADRLKLR PRAPADDMFG VGNHKANAET AKRKSIRRRH TLGGHRDATE
ISVLNFWKVH EQSGERESEL SAVNRLKPKC SAQDLSISDW LARERLRTST SDLSRGEIGD
PQTENPSTRE TATTDTPLSF QCDTGSSSST LASTNRPLLS IPPQSSDQIN GESFQNVSKN
ASSAANAQPR KLSETPGNKA EFHPCL
//
