ID A0A2K5MRJ8_CERAT Unreviewed; 4817 AA.
AC A0A2K5MRJ8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSCATP00000027819.1};
GN Name=RYR2 {ECO:0000313|Ensembl:ENSCATP00000027819.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000027819.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000027819.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671,
CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR Ensembl; ENSCATT00000052066.1; ENSCATP00000027819.1; ENSCATG00000037204.1.
DR GeneTree; ENSGT00940000154906; -.
DR OMA; HYEDTSD; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000037204; Expressed in heart and 8 other cell types or tissues.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 1.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF7; RYANODINE RECEPTOR 2; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 3.
DR Pfam; PF00622; SPRY; 2.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 661..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4160..4179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4380..4400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4454..4473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4564..4581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4618..4639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4694..4717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 100..155
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 215..270
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 276..333
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 341..398
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 922..1119
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1234..1459
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3903..3938
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 568..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1753..1788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2251..2276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4090..4109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4295..4347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..815
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4092..4109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4298..4347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4817 AA; 545762 MW; E3DAE51AF807DAEF CRC64;
MLSDHSDSGE EDDEVVLQCT ATIHKEQQKL CLAAEGFGNR LCFLESTSNS KNVPPDLSIC
TFVLEQSLSV RALQEMLANT VEKSEGQVDV EKWTAQGGGH RTLLYGHAIL LRHSYSGMYL
CCLSTSRSST DKLAFDVGLQ EDTTGEACWW TIHPASKQRS EGEKVRVGDD LILVSVSSER
YLHLSYGNGS LHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH MDECLTVPSG
EHGEEQRRTV HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV TTGKYLSLME
DKNLLLMDKE KADVKSTAFT FRSSKEKLDV GVRKEVDGMG TSEIKYGDSV CYIQHVDTGL
WLTYQSVDVK SVRMGSIQRK AIMHHEGHMD DGISLSRSQH EESRTARVIR STVFLFNRFI
RGLDALSKKA KATTVDLPIE SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR ALKNRQNLFQ
EEGMINLVLE CIDRLHVYSS AAHFADVAGR EAGDSWKSIL NSLYELLGKK HDWVHDNGVM
EGGSTEILLL LLLLLLLCSL CVCHGVSSSS SSSSSSDNLL PGRDLFPPPP PPPPPPSMRP
NILLLLLLLL LQYKKWYYEL MSSSSSSSSS SEATHLRVGW ASTEGYSPYP GGGEEWGGNG
VLLLLLLLLL HGLHLWSGCI ALLLLLLLLL LLRTDDVISC CSSSSSSSSS SRINGQPVQG
MFENFNIDGL FFPVVSFSIK RTLTPPPPPP PPPPGGRHGE FKFLLLLLLL LLLQAVLPKE
KLKSSSSSSS SSSRTYTRDL LGPPPPPPPP PPPPIPVDTS QVLLLLLLLL LLHAVILIHS
GPENDVYRDF YEKANYIEMS LSLICSYQLT SGYKPAPMDL SFIKLTPSQE AMVDKLAENA
HNVWARDRIR QGWTYGIQQD VKNRRNPRLV PYTLLDDRTK KSNKDSLREA VRTLLGYGYN
LEAPDQDHAA RAEVCSGTGE RFRIFRAEKT YAVKAGRWYF EFETVTAGDM RVGWSRPGCQ
PDQELGSDER AFAFDGFKAQ RWHQGNEHYG RSWQAGDVVG CMVDMNEHTM MFTLNGEILL
DDSGSELAFK DFDVGDGFIP VCSLGVAQVG RMNFGKDVST LKYFTICGLQ EGYEPFAVNT
NRDITMWLSK RLPQFLQVPS NHEHIEVTRI DGTIDSSPCL KVTQKSFGSQ NSHTDIMFYR
LSMPIECAEV FSKTVAGGLP GAGLFGPKND LEDYDADSDF EVLMKTAHGH LVPDRVDKDK
EATKPEFNNH KDYAQEKPSR LKQRFLLRRT KPDYSTSHSA RLTEDVLADD RDDYDFLMQT
STYYYSVRIF PGQEPANVWV GWITSDFHQY DTGFDLDRVR TVTVTLGDEK GKVHESIKRS
NCYMVCAGES MSPGQGRNNN GLEIGCVVDA ASGLLTFIAN GKELSTYYQV EPSTKLFPAV
FAQATSPNVF QFELGRIKNV MPLSAGLFKS EHKNPVPQCP PRLHVQFLSH VLWSRMPNQF
LKVDVSRISE RQGWLVQCLD PLQFMSLHIP EENRSVDILE LTEQEELLKF HYHTLRLYSA
VCALGNHRVA HALCSHVDEP QLLYAIENKY MPGLLRAGYY DLLIDIHLSS YATARLMMNN
EYIVPMTEET KSITLFPDEN KKHGLPGIGL STSLRPRMQF SSPSFVSVSN ECYQYSPEFP
LDILKAKTIQ MLTEAVKEGS LHARDPVGGT TEFLFVPLIK LFYTLLIMGI FHNEDLKHIL
QLIEPSVFKE AATPEEESDT LEKELSVDDA KLQGAGEEEA KGGKRPKEGL LQMKLPEPVK
LQMCLLLQYL CDCQVRHRIE AIVAFSDDFV AKLQDNQRFR YNEVMQALNM SAALTARKTK
EFRSPPQEQI NMLLNFKDDK SECPCPEEIR DQLLDFHEDL MTHCGIELDE DGSLDGNSDL
TIRGRLLSLV EKVTYLKKKQ AEKPVESDSK KSSTLQQLIS ETMVRWAQES VIEDPELVRA
MFVLLHRQYD GIGGLVRALP KTYTINGVSV EDTINLLASL GQIRSLLSVR MGKEEEKLMI
RGLGDIMNNK VFYQHPNLMR ALGMHETVME VMVNVLGGGE SKEITFPKMV ANCCRFLCYF
CRISRQNQKA MFDHLSYLLE NSSVGLASPA MRGSTPLDVA AASVMDNNEL ALALREPDLE
KVVRYLAGCG LQSCQLLVSK GYPDIGWNPV EGERYLDFLR FAVFCNGESV EENANVVVRL
LIRRPECFGP ALRGEGGNGL LAAMEEAIKI AEDPSRDGPS PNSGSSKTLD TEEEEDDTIH
MGNAIMTFYA ALIDLLGRCA PEMHLIHAGK GEAIRIRSIL RSLIPLGDLV GVISIAFQMP
TIAKDGNVVE PDMSAGFCPD HKAAMVLFLD RVYGIEVQDF LLHLLEVGFL PDLRAAASLD
TAALSATDMA LALNRYLCTA VLPLLTRCAP LFAGTEHHAS LIDSLLHTVY RLSKGCSLTK
AQRDSIEVCL LSICGQLRPS MMQHLLRRLV FDVPLLNEHA KMPLKLLTNH YERCWKYYCL
PGGWGNFGAA SEEELHLSRK LFWGIFDALS QKKYEQELFK LALPCLSAVA GALPPDYMES
NYVSMMEKQS SMDSEGNFNP QPVDTSNITI PEKLEYFINK YAEHSHDKWS MDKLANGWIY
GEIYSDSSKV QPLMKPYKLL SEKEKEIYRW PIKESLKTML AWGWRIERTR EGDSMALYNR
TRRISQTSQV SVDAAHGYSP RAIDMSNVTL SRDLHAMAEM MAENYHNIWA KKKKMELESK
GGGNHPLLVP YDTLTAKEKA KDREKAQDIL KFLQINGYAV SRGFKDLELD TPSIEKRFAY
SFLQQLIRYV DEAHQYILEF DGGSRGKGEH FPYEQEIKFF AKVVLPLIDQ YFKNHRLYFL
SAASRPLCSG GHASNKEKEM NIEKFSGQFI RHFVSSSGND ATSIVNCLHI LGQTLDARTV
MKTGLESVKS ALRAFLDNAA EDLEKTMENL KQGQFTHTRN QPKGVTQIIN YTTVALLPML
SSLFEHIGQH QFGEDLILED VQVSCYRILT SLYALGTSKS IYVERQRSAL GECLAAFAGA
FPVAFLETHL DKHNIYSIYN TKSSRERAAL SLPTNVEDVC PNIPSLEKLM EEIVELAESG
IRYTQMPHVM EVILPMLCSY MSRWWEHGPE NNPERVEMCC TALNSEHMNT LLGNILKIIY
NNLGIDEGAW MKRLAVFSQP IINKVKPQLL KTHFLPLMEK LKKKAAMVVS EEDHLKAEAR
GDMSEAELLI LDEFTTLARD LYAFYPLLIR FVDYNRAKWL KEPNPEAEEL FRMVAEVFIY
WSKSHNFKRE EQNFVVQNEI NNMSFLITDT KSKMSKAAVS DQERKKMKRK GDRYSMQTSL
IVAALKRLLP IGLNICAPGD QELIALAKNR FSLKDTEDEV RDIIRSNIHL QGKLEDPAIR
WQMALYKDLP NRTDDTSDPE KTVERVLDIA NVLFHLEQKS KRVGRRHYCL GSTVEHPQRS
KKAVWHKLLS KQRKRAVVAC FRMAPLYNLP RHRAVNLFLQ GYEKSWIETE EHYFEDKLIE
DLAKPGADPP EEDEGTKRVD PLHQLILLFS RTALTEKCCH DEEDDDGEEE VKSFEEKEME
KQKLLYQQAR LHDRGAAEMV LQTISASKGE TGPMVAATLK LGIAILNGGN STVQQKMLDY
LKEKKDVGFF QSLAGLMQSC SVLDLNAFER QNKAEGLGMV TEEGSGEKVL QDDEFTCDLF
RFLQLLCEGH NSDFQNYLRT QTGNNTTVNI IISTVDYLLR VQESISDFYW YYSGKDVIDE
QGQRNFSKAI QVAKQVFNTL TEYIQGPCTG NQQSLAHSRL WDAVVGFLHV FAHMQMKLSQ
DSSQIELLKE LMDLQKDMVV MLLSMLEGNV VNGTIGKQMV DMLVESSNNV EMILKFFDMF
LKLKDLTSSD TFKEYDPDGK GVISKRDFHK AMESHKHYTQ SETEFLLSCA ETDENETLDY
EEFVKRFHEP AKDIGFNVAV LLTNLSEHMP NDTRLQTFLE LAESVLNYFQ PFLGRIEIMG
SAKRIERVYF EISESSRTQW EKPQVKESKR QFIFDVVNEG GEKEKMELFV NFCEDTIFEM
QLAAQISESD LNERSANKED SEKERPEEQG PRMAFFSILT VKSALFALRY NILTLMRMLS
LKSLKKQMKK VKKMTVKDMV TAFFSSYWSI FMTLLHFVAS VFRGFFRIIC SLLLGGSLVE
GAKKIKVAEL LANMPDPTQD EVRGDGEEGE RKTLEAALPS EDLTDLKELT EESDLLSDIF
GLDLKREGGQ YKLIPHNPNA GLSDLMSNPV PMPEVQEKFQ EQKAKEEEKE EKEETKSEPE
KAEGEDGEKE EKAKEDKGKQ KLRQLHTHRY GEPEVPESAF WKKIIAYQQK LLNYFARNFY
NMRMLALFVA FAINFILLFY KVSTSSVVEG KELPTRSSSE NAKVTSLDSS SHRIIAVHYV
LEESSGYMEP TLRILAILHT VISFFCIIGY YCLKVPLVIF KREKEVARKL EFDGLYITEQ
PSEDDIKGQW DRLPTKCFFS YPKVMDKYGE FYGRDRISEL LGMDKAALDF SDAREKKKPK
KDSSLSASFL YLAWYMTMSV LGHYNNFFFA AHLLDIAMGF KTLRTILSSV THNGKQLVLT
VGLLAVVVYL YTVVAFNFFR KFYNKSEDGD TPDMKCDDML TCYMFHMYVG VRAGGGIGDE
IEDPAGDEYE IYRIIFDITF FFFVIVILLA IIQGLIIDAF GELRDQQEQV KEDMETKCFI
CGIGNDYFDT VPHGFETHTL QEHNLANYLF FLMYLINKDE TEHTGQESYV WKMYQERCWE
FFPAGDCFRK QYEDQLN
//
