ID   A0A2K5MSJ1_CERAT        Unreviewed;       348 AA.
AC   A0A2K5MSJ1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit beta {ECO:0000256|RuleBase:RU362099};
GN   Name=ATP1B4 {ECO:0000313|Ensembl:ENSCATP00000028169.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000028169.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000028169.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: May act as a transcriptional coregulator during muscle
CC       development through its interaction with SNW1. Has lost its ancestral
CC       function as a Na,K-ATPase beta-subunit.
CC       {ECO:0000256|ARBA:ARBA00037398}.
CC   -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC       which catalyzes the hydrolysis of ATP coupled with the exchange of
CC       Na(+) and K(+) ions across the plasma membrane.
CC       {ECO:0000256|RuleBase:RU362099}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC       pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}. Nucleus
CC       inner membrane {ECO:0000256|ARBA:ARBA00037816}; Single-pass type II
CC       membrane protein {ECO:0000256|ARBA:ARBA00037816}.
CC   -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC       {ECO:0000256|ARBA:ARBA00005876, ECO:0000256|RuleBase:RU362099}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K5MSJ1; -.
DR   Ensembl; ENSCATT00000052420.1; ENSCATP00000028169.1; ENSCATG00000037392.1.
DR   GeneTree; ENSGT01030000234579; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000037392; Expressed in skeletal muscle tissue.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 2.60.40.1660; Na, k-atpase alpha subunit; 2.
DR   InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR   InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR   NCBIfam; TIGR01107; Na_K_ATPase_bet; 1.
DR   PANTHER; PTHR11523:SF12; PROTEIN ATP1B4; 1.
DR   PANTHER; PTHR11523; SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT; 1.
DR   Pfam; PF00287; Na_K-ATPase; 1.
DR   PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
DR   PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|RuleBase:RU362099};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362099};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362099};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362099}; Transport {ECO:0000256|RuleBase:RU362099}.
FT   TRANSMEM        108..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362099"
FT   REGION          26..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..72
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   348 AA;  40794 MW;  30D618FB94D51BE7 CRC64;
     MRRQLRSRRA PSFPYSYRYR LDDPDEVNQN YLADEEEEAE EEARVTVVPK SEEEEEEEEK
     EEEEEEEKEE EEGQGQPTGN AWWQKLQIMN EYLWDPERRM FLARTGQSWS LILLVYFFFY
     ASLAAVITLC MYTLFLTISP YIPTFTERVK PPGVMIRPFA HSLNFNFNVS EPDTWQHYVI
     SLNGFLQGYN DSLQEEMNVD CPPGQYFIQD GNEDEDKKAC QFKRSFLKNC SGLEDPTFGY
     STGQPCILLK MNRHPTYTCF CLQRGDENDI RSISYYPESA SFDLRYYPYY GKLTHVNYTS
     PLVAMHFTDV VKNQAVPVQC QLKGKGIIND VINDRFVGRV IFTLNIET
//