ID A0A2K5MSM3_CERAT Unreviewed; 350 AA.
AC A0A2K5MSM3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Izumo sperm-oocyte fusion 1 {ECO:0000313|Ensembl:ENSCATP00000028216.1};
GN Name=IZUMO1 {ECO:0000313|Ensembl:ENSCATP00000028216.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000028216.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000028216.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Izumo family.
CC {ECO:0000256|ARBA:ARBA00009633}.
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DR AlphaFoldDB; A0A2K5MSM3; -.
DR STRING; 9531.ENSCATP00000028216; -.
DR Ensembl; ENSCATT00000052467.1; ENSCATP00000028216.1; ENSCATG00000037416.1.
DR GeneTree; ENSGT00390000015014; -.
DR OMA; ATIINFH; -.
DR Proteomes; UP000233060; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IEA:Ensembl.
DR GO; GO:0035036; P:sperm-egg recognition; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029389; IZUMO.
DR InterPro; IPR032699; Izumo-Ig.
DR InterPro; IPR032700; IZUMO1.
DR PANTHER; PTHR35540; IZUMO SPERM-EGG FUSION PROTEIN 1; 1.
DR PANTHER; PTHR35540:SF1; IZUMO SPERM-EGG FUSION PROTEIN 1; 1.
DR Pfam; PF15005; IZUMO; 1.
DR Pfam; PF16706; Izumo-Ig; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..350
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014335909"
FT TRANSMEM 293..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 168..255
FT /note="Izumo protein immunoglobulin"
FT /evidence="ECO:0000259|Pfam:PF16706"
FT REGION 260..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 350 AA; 39256 MW; 4F59DC35464850DD CRC64;
MGPHFTLLCA ALAGCLLPAE ECVICDPSVV LALKSLEKDY LPGHLDAKHH KAMMERVEKA
VKDFQELSLN EDTYMGVVDE ATLQKGSWSL LKDLKRITDS DVKGDLFVKE LFWMLHLQKE
TFATYVARFQ KEAYCPNKCG MMLQTLIWCK NCKKEVHACR KSYDCGERNV EVPQMEDMIL
DCELNWHQAS EGLTDYSFYR VWGNNTETLV SKGKEPILTK SMVGPEDAGS YRCELGSVNS
SPATVINFRV TVLPKRVEEE KPSPNIVTPG EATTESSNTL QPLKPEKMLK GRLLGLLIWG
SLALITGITF AIFCRRKVID FIKSSLFGLG SGVVEQPQVP KEKATDSRHQ
//
