ID A0A2K5MU74_CERAT Unreviewed; 646 AA.
AC A0A2K5MU74;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 {ECO:0008006|Google:ProtNLM};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000028746.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000028746.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR AlphaFoldDB; A0A2K5MU74; -.
DR STRING; 9531.ENSCATP00000028746; -.
DR Ensembl; ENSCATT00000053001.1; ENSCATP00000028746.1; ENSCATG00000037641.1.
DR GeneTree; ENSGT00940000163475; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000037641; Expressed in skeletal muscle tissue and 9 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45819:SF8; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 11; 1.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 270..431
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 428..551
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 583..615
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 191..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 71058 MW; DDB98516A2A9E968 CRC64;
MGNILTCCVC PRISPEFDQQ QGSVCPSESE IYEAGAGDRM AGAGDGPAAV TVEVGEDLHM
HHIHDREMPE ALEFNPSANP GASTIFQRNC QTDALEFNPS ANSEASTIFQ RNSQTDVVEI
RRSNCTNHVI STVRFSQQYS SSSTILLDDS TASQPYLTMT IISDADGSLT LFDEHHSSFC
STQVSTMHIT QMRNGGGSFS NDSSSIPSTP STSQEDLQIN VPPTANTPTP VRKQSKHWSK
LFTSKKGSDP DKENKARESH ADTIRSGRAI PIKQGMLLKL SGKWLKKWKK KYVTLCDNGM
LTYYSSLGDY MKNIHKKEID LRTCTIKVPG KRPPLATLAC VPISSSKSNG LSKDMNNTGL
SDSICSSPNI SSTTSPKLSP PPSPHANKRK HGRKKKENFI IVSLTGQTWH FEATSYEKRD
AWVQAIESQI LASLQSCESS KSKPWSCSPS ETCGNSHCVH CETQNPNWAS LNLGVLMCIE
CSGIHCNLGT RLSRLMQVLS SIGNELANSI WQESSQGRMK PSVDSTREEK EWWNRAKYEQ
KLFLAPLPSR ELSLGQHLLQ ATADEDLRTA ILLLVNETCG EGDSCTALHL ACRKGNVVLA
QLLIWYGMDV MAGDAHENTA LAYARQASSQ ECIKVRLQYS CPDEHV
//
