ID A0A2K5MUE6_CERAT Unreviewed; 935 AA.
AC A0A2K5MUE6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5D {ECO:0000313|Ensembl:ENSCATP00000028863.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000028863.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000028863.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR AlphaFoldDB; A0A2K5MUE6; -.
DR Ensembl; ENSCATT00000053118.1; ENSCATP00000028863.1; ENSCATG00000037689.1.
DR GeneTree; ENSGT00950000182815; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000037689; Expressed in frontal cortex and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd08801; Death_UNC5D; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR042058; UNC5D_Death.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 362..385
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 148..226
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 524..664
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 935 AA; 104423 MW; 5EBC0D01449CB1FB CRC64;
MCYQCRLYSD VLFGFTGTDN GEALPESIPS APGTLPHFIE EPDDAYIIKS NPIALRCKAR
PAMQIFFKCN GEWVHQNEHV SEESLDESSG LKVREVFINV TRQQVEDFHG PEDYWCQCVA
WSHLGTSKSR KASVRIAYLR KNFEQDPQGR EVPIEGMIVL HCRPPEGVPA AEVEWLKNEE
PIDSEQDENI DTRADHNLII RQARLSDSGN YTCMAANIVA KRRSLSATVV VYVNGGWSSW
TEWSACNVRC GRGWQKRSRT CTNPAPLNGG AFCEGMSVQK ITCTSLCPVD GSWEVWSEWS
VCSPECEHLR IRECTAPPPR NGGKFCEGLS QESENCTDGL CILDKKPLHE IKPQSIENAS
DIALYSGLGA AVVAVAVLVI GVTLYRRSQS DYGVDVIDSS ALTGGFQTFN FKTVRQGNSL
LLNSAMQPDL TVSRTYSGPI CLQDPLDKEL MTESSLFNPL SDIKVKVQSS FMVSLGVSER
AEYHGKNHSR TFPHGNNHSF STMHPRNKTP YIQNLSSLPT RTELRTTGVF GHLGGRLVMP
NTGVSLLIPH GAIPEENSWE IYMSINQGEP SLQSDGSEVL LSPEVTCGPP DMIVTTPFAL
TIPHCADVSS EHWNIHLKKR TQQGKWEEVM SVEDESTSCY CLLDPFACHV LLDSFGTYAL
TGEPITDCAV KQLKVAVFGC MSCNSLDYNL RVYCVDNTPC AFQEVVSDER HQGGQLLEEP
KLLHFKGNTF SLQISVLDIP PFLWRIKPFT ACQEVPFSRV WCSNRQPLHC AFSLERYTPT
TTQLSCKICI RQLKGHEQIL QVQTSILESE RETITFFTQE DSTFPAQTGP KAFKIPYSIR
QRICATFDTP NAKGKDWQML AQKNSINRNL SYFATQSSPS AVILNLWEAR HQHDGDLDSL
ACALEEIGRT HTKLSNISES QLDEADFNYS RQNGL
//
