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Database: UniProt
Entry: A0A2K5MUF3_CERAT
LinkDB: A0A2K5MUF3_CERAT
Original site: A0A2K5MUF3_CERAT 
ID   A0A2K5MUF3_CERAT        Unreviewed;       415 AA.
AC   A0A2K5MUF3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   10-APR-2019, entry version 6.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=HYAL4 {ECO:0000313|Ensembl:ENSCATP00000028862};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000028862, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000028862, ECO:0000313|Proteomes:UP000233060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y., Hughes D.S., Murali S., Raveendran M., Korchina V., Wang M.,
RA   Jhangiani S., Bandaranaike D., Bellair M., Blankenburg K., Chao H.,
RA   Dahdouli M., Dinh H., Doddapaneni H., English A., Firestine M.,
RA   Gross S., Hernandez B., Javaid M., Jayaseelan J., Jones J., Joshi V.,
RA   Khan Z., Kovar C., Lee S., Newsham I., Nguyen L., Okwuonu G.,
RA   Ongeri F., Osuji N., Pu L.-L., Puazo M., Qu C., Quiroz J., Raj R.,
RA   Reid J.G., Santibanez J., Scheel M., Sexton D., Shah N., Skinner E.,
RA   Vee V., Wu Y., Han Y., Muzny D.M., Richards S., Worley K.C.,
RA   Rogers J., Gibbs R.A.;
RT   "Sooty reference genome and diversity panel.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCATP00000028862}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   Ensembl; ENSCATT00000053117; ENSCATP00000028862; ENSCATG00000037698.
DR   GeneTree; ENSGT00950000182708; -.
DR   Proteomes; UP000233060; Whole Genome Shotgun Assembly.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000233060};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    415       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014462243.
FT   ACT_SITE    135    135       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    357    357       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     47    340       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    211    227       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    365    376       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   415 AA;  47713 MW;  F4F1B63C670E2F6D CRC64;
     MCNPWVAWLG VLPLFILLTQ AALKPAMPPV IDSQPFSIFW AAPTMYCMPF FNVNMNLQVF
     NIISNPLETQ SGSKIAIIYP NELGYYPYFS QDGKSFNGGI PQNVSLSEHL RKAADDIGEA
     VPWWRSEGLV VIDWESWKPQ WDRNRGSRII YNNHSLAFTR NHHPYWSEMK VETVAREEFE
     NAGKNFMNVT LTLALEMRPK CLWGFYLYPD CYNYDYRINP ETYTGNCPND EILRNDQLLW
     LWEKSAALYP SIYLDKILKS SLNALKFVHY RVREAMRIAE MARHDYVLPV FIFSRPFYLH
     STEALSQEDL VHTIGESAAL GAAGVILWGG YEYSASKENC LSMQQSIRGP LGHYAVNVTS
     AAKLCSQNLC NNHGRCIRKT PESSFYLHMP ESSGLLEYTK VEDNIRFLSY HESVI
//
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