ID   A0A2K5MUH6_CERAT        Unreviewed;       935 AA.
AC   A0A2K5MUH6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease {ECO:0000313|Ensembl:ENSCATP00000028887.1};
GN   Name=DIS3 {ECO:0000313|Ensembl:ENSCATP00000028887.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000028887.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000028887.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC       {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
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DR   RefSeq; XP_011941478.1; XM_012086088.1.
DR   AlphaFoldDB; A0A2K5MUH6; -.
DR   Ensembl; ENSCATT00000053142.1; ENSCATP00000028887.1; ENSCATG00000037705.1.
DR   GeneID; 105597641; -.
DR   CTD; 22894; -.
DR   GeneTree; ENSGT00530000063106; -.
DR   OrthoDB; 945235at2759; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000037705; Expressed in lymph node and 12 other cell types or tissues.
DR   GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR   CDD; cd09862; PIN_Rrp44-like; 1.
DR   Gene3D; 2.40.50.690; -; 1.
DR   Gene3D; 2.40.50.700; -; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR033771; Rrp44_CSD1.
DR   InterPro; IPR033770; RRP44_S1.
DR   PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR   PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF13638; PIN_4; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF17216; Rrp44_CSD1; 1.
DR   Pfam; PF17215; Rrp44_S1; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   3: Inferred from homology;
KW   Exosome {ECO:0000256|ARBA:ARBA00022835};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022722};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          444..774
FT                   /note="Ribonuclease II/R"
FT                   /evidence="ECO:0000259|SMART:SM00955"
FT   REGION          913..935
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   935 AA;  105936 MW;  6FDEAAE6A6A7F29A CRC64;
     MLKSKTFLKK TRAGGVMKIV REHYLRDDIG CGAPGCAACG GAHEGPALEP QPQDPASSLC
     PQPHYLLPDT NVLLHQIVSA WRLGTWASVA SSLRLPGSLC LRTKTIETYV EQEQGENAND
     RNDRAIRVAA KWYNEHLKKM SADNHLQVIF ITNDRKNKEK AVEEGIPAFT CEEYVKSLTA
     NPELIDRLAC LSEEVNEIES GKIIFSEHLP LSKLQQGIKS GTYLQGTFRA SRENYLEATV
     WIHGDNEENK EIILQGLKHL NRAVHEDIVA VELLPKSQWV APSSVVLQDE GQNEEDVEKE
     EERERMLKTA VSEKMLKPTG RVVGIIKRNW RPYCGMLSKS DIKESRRHLF TPADKRIPRI
     RIETRQASTL EGRRIIVAID GWPRNSRYPN GHFVRNLGDV GEKETETEVL LLEHDVPHQP
     FSQAVLSFLP KMPWSITEKD MKNREDLRHL CICSVDPPGC TDIDDALHCR ELENGNLEVG
     VHIADVSHFI RPGNALDQES ARRGTTVYLC EKRIDMVPEL LSSNLCSLKC DVDRLAFSCI
     WEMNHNAEIL KTKFTKSVIN SKASLTYAEA QLRIDSANMN DDITTSLRGL NKLAKILKKR
     RIEKGALTLS SPEVRFHMDS ETHDPIDLQT KELRETNSMV EEFMLLANIS VAKKIHEEFS
     EHALLRKHPA PPPSNYEILV KAARSRNLEI KTDTAKSLAE SLDRAESPTF PYLNTLLRIL
     ATRCMMQAVY FCSGMDNDFH HYGLASPIYT HFTSPIRRYA DVIVHRLLAV AVGADCTYPE
     LTDKHKLADI CKNLNFRHKM AQYAQRASVA FHTQLFFKSK GIVSEEAYIL FVRKNAIVVL
     IPKYGLEGTV FFEEKDKPNP RLIYDDEIPS LKIEDTVFHV FDKVKVKIML DSSNLQHQKI
     RMSLVEPQIP GISIPTDTSN TDLNGPEKKK IKLGK
//