ID A0A2K5MUX9_CERAT Unreviewed; 1784 AA.
AC A0A2K5MUX9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=TSC complex subunit 2 {ECO:0000313|Ensembl:ENSCATP00000029039.1};
GN Name=TSC2 {ECO:0000313|Ensembl:ENSCATP00000029039.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000029039.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000029039.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011888654.1; XM_012033264.1.
DR Ensembl; ENSCATT00000053294.1; ENSCATP00000029039.1; ENSCATG00000037504.1.
DR GeneID; 105573530; -.
DR CTD; 7249; -.
DR GeneTree; ENSGT00950000183139; -.
DR OrthoDB; 20915at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000037504; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR003913; Tuberin.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR PRINTS; PR01431; TUBERIN.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 1508..1735
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 655..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1304..1326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1742..1769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1347..1371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1446..1461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1784 AA; 198192 MW; FE8CDFA3423BB890 CRC64;
MAKPTSKDSG LKEKFRILFG LGTPRPNPRS AEGKQTEFII TAEILRELSV ECGLSNRIRM
IGQICEVAKT KKFEEHAVEA LWKAVADLLQ PERPLEARHA VLALLKAIIQ GQGERLGVLR
ALFFKVIKDY PSNEDLHERL DVFKALTDNG RHITYLEEEL ADFVLQWMDV GLSSEFLLVL
VNLVKFNSCY LDEYIARMVQ MICLLCVRTA SSVDIEVSLQ VLDAVVCYNC LPAESLPLFI
VTLCRTINVK ELCEPCWKLM RNLLGTHLGH SAIYNMCHLM EDRAYMEDAP LLRGAVFFVG
MALWGAHRLY SLRNSPTSVL PSFYQAMACP NEVVSYEIVL SITRLIKKYR KELQVVTWDI
LLNIIERLLQ QLQTLDSPEL RTIVHDLLTT VEELCDQNEF HGSQERYFEL VERCADQRPE
SSLLNLISYR AQSIHPAKDG WIQNLQALME RFFRSESRGA VRIKVLDVLS FVLLINRQFY
EEELINSVVI SQLSHIPEDK DHQVRKLATQ LLVDLAEGCH THHFNSLLDI IEKVMARSLS
PPPELEERDV AAYSASLEDV KTAVLGLLVI LQTKLYTLPA SHATRVYEML VSHIQLHYKH
SYTLPIASSI RLQAFDFLLL LRADSLHRLG LPNKDGVVRF SPYCVCDYME PERGSEKKAS
GPLSPPTGPP GPAPAGPAVR LGSLPYSLLF RVLLQCLKQE SDWKVLKLVL GRLPESLRYK
VLIFTSPCSV DQLCSALCSM LSGPKTLERL RGAPEGFSRT DLHLAVVPVL TALISYHNYL
DKTKQREMVY CLEQGLIHRC ASQCVVALSI CSVEMPDIMI KALPVLVVKL THISATASMA
VPLLEFLSTL ARLPQLYRNF AAEQYASVFA ISLPYTNPSK FNQYIVCLAH HVIAMWFIRC
RLPFRKDFVP FITKGLRSNV LLSFDDTPEK DSFRARSTSL NERPKSLRIA RPPKQGLNNS
PPMKEFKESS AAEAFRCRSI SVSEHVVRSR IQTSLTSASL GSADENSMAQ ADDSLKSLHL
ELTETCLDMM ARYVFSNFTA VPKRSPVGEF LLAGGRTKTW LVGNKLVTVT TSVGTGTRSL
LGLDSGELQS GPESSSSPGM NVRQTKEAPA KLESQAGQQV SRGARDRVRS MSGGHGLRVG
ALDVPASQFP GSAASPGPQT TPAAKPEKAS AGTRLPVQEK TNLAAYVPLL TQGWAEILVR
RPTGNTSWLM SLENPLSPFS SDINNMPLQE LSNALMAAER FKEHRDTALY KSLSVPAAST
AKPPPLPRSN TDSAVVMEEG SPGEVPVPVE PPGLEDFEAA LGVDRRTDAY SRSSSTSSQE
EKSFHAEELV AGGIPIERAV SSEGGRPSVD LSFQPSQPLS KSSSSPELQT LQDILGDPGD
KADVGRLSPE VKARSQSGIL DGESAAWPAS GEDSRGQPEG PLPSSSPRSP SGLRPRGYTI
SDSAPSRRGR RVERDAFKSR ATASNAEKVP GINPSFVFLQ LYHSPFFGDE SNKPILLPNE
SQSFERSVQL LDQIPSYDTH KIAVLYVGEG QSNSELAILS NEHGSYRYTE FLTGLGRLIE
LKDCQPDKVY LGGLDVCGED GQFTYCWHDD IMQAVFHIAT LMPTKDVDKH RCDKKRHLGN
DFVSIVYNDS GEDFKLGTIK GQFNFVHVII TPLDYECNLV SLQCRKDMEG LVDTSVAKIV
SDRNLPFVAR QMALHANMAS QVHHSRSNPT DIYPSKWIAR LRHIKRLRQR ICEEAAYSNP
SLPLVHPPSH TKGPAQTPAE PTPGYEMGQR KRLISSVEDF TEFV
//
