ID A0A2K5MVH1_CERAT Unreviewed; 1058 AA.
AC A0A2K5MVH1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Nuclear factor of activated T cells 3 {ECO:0000313|Ensembl:ENSCATP00000029196.1};
GN Name=NFATC3 {ECO:0000313|Ensembl:ENSCATP00000029196.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000029196.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000029196.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5MVH1; -.
DR Ensembl; ENSCATT00000053452.1; ENSCATP00000029196.1; ENSCATG00000037849.1.
DR GeneTree; ENSGT00940000156131; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000037849; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF6; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 416..597
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1058 AA; 115414 MW; 09F9CDE88AF98986 CRC64;
MTTANCRPHD ELELQTRLGE DGARPPPPPR SRLQVDLEPD DCASIYIFNV DPPPSTLNTP
LCLPHHGLPS HSSVLSPSFQ LQSHKNYEGT CESPESKYSP LGGPKPFECP SIQITSISPN
CHQEIDAHED DLQINDPERE FLERPSRDHL YLPLEPSYRE SSLSPSPASS ISSRSWFSDA
SSCESLSHIY DDVDSELNEA AARFTLGSPL TSPGGSPGGC PGEETWHQQY GLGHSLSPRQ
SPCHSPRSSV TDENWLSPRP ASGPSSRPTS PCGKRRHSSA EVCYAGSLSP HHSPVPSPGH
SPRGSVTEDT WLNASVHGGS GFGPAVFPFQ YCVETDIPLK TRKTSEDQAA IVPGKLELCS
DDQGSLSPSR ETSIDDGLGS QYPLKKDSSG DQFLSVPSPF TWSKPKPGHT PIFRTSSLPP
LDWPLPAHFG QCELKIEVQP KTHHRAHYET EGSRGAVKAS TGGHPVVKLL GYNEKPINLQ
MFIGTADDRY LRPHAFYQVH RITGKTVATA SQEIIIASTK VLEIPLLPEN NMSASIDCAG
ILKLRNSDIE LRKGETDIGR KNTRVRLVFR VHIPQPNGKV LSLQIASIPV ECSQRSAQEL
PHIEKYSINS CSVNGGHEMI VTGSNFLPES KIIFLEKGQD GRPHWEVEGK IIREKCQGAH
IVLEVPPYHN PAVTAAVQVH FYLCNGKRKK SQSQRFTYTP VLMKQEHREE IDLSSVPSLP
VPHPAQTQRP SSDSGHSRDS VLSAQRSLVC SIPQTYASMV TSSHLPQLQC REKKKSKEQH
MIPSPVVHQP FQVTPTPPVG SSYQPMQTNV VYKKKNCLPI NAASSQEFDS VLFQQDATLP
GLVNLGCQPL SSIPFHSSNS GSTGHLLAHT PHSKKKKPHL QSMGYHLTDQ ITGQPSSQLQ
PVKKKTSHSG SATTASPAAS HPKKKKPLSG PPSPQLQSMP YQSPSSGTAS SPSPATRMHS
GQQKKKTQST GQGGLSAPSS LICKKKNDPA SFPPDGATVS IKPEKKKREP NFATIGLSDV
VFFDTDQFIS DLEHQPSGSA EKWPNHSVLS CPAPFWRI
//
