ID A0A2K5MW05_CERAT Unreviewed; 1654 AA.
AC A0A2K5MW05;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 {ECO:0000313|Ensembl:ENSCATP00000029417.1};
GN Name=PREX1 {ECO:0000313|Ensembl:ENSCATP00000029417.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000029417.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000029417.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSCATT00000053675.1; ENSCATP00000029417.1; ENSCATG00000037943.1.
DR GeneTree; ENSGT00940000159925; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000037943; Expressed in spleen and 12 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:UniProt.
DR CDD; cd04440; DEP_2_P-Rex; 1.
DR CDD; cd00136; PDZ; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 51..242
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 273..394
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 423..498
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 531..599
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1654 AA; 185846 MW; 2F111BE46177AF22 CRC64;
MEAPSGSEPS GDGAGTAPTR TPGNPWRAAP SSGPGPGPCS AARESERQLR LRLCVLNEIL
GTERDYVGTL RFLQSAFLHR IRQNVADSVE KGLTEENVKI LFSNIEDILE VHKDFLAALE
YCLHPEPQSQ HELGNVFLKF KDKFCVYEEY CSNHEKALRL LVELNKIPTV RAFLLSCMLL
GGRKTTDIPL EGYLLSPIQR ICKYPLLLKE LAKRTPGKHP DHPAVQSALQ AMKTVCSNIN
ETKRQMEKLE ALEQLQSHIE GWEGSNLTDI CTQLLLQGTL LKISAGNIQE RAFFLFDNLL
VYCKRKSRVT GSKKSTKRTK SINGSLYIFR GRINTEVMEV ENVEDGTADY HSNGYTVTNG
WKIHNTAKNK WFVCMAKTAE EKQKWLDAII REREQRESLK LGMERDAYVM IAEKGEKLYH
MMMNKKVNLI KDRRRKLSTV PKCFLGNEFV AWLLEIGEIS KTEEGVNLGQ ALLENGIIHH
VSDKHQFKNE QVMYRFRYDD GTYKARSELE DIMSKGVRLY CRLHSLYTPV IKDRDYHLKT
YKSVLPGSKL VDWLLAQGDC QTREEAVALG VGLCNNGFMH HVLEKSEFRD ESQYFRFHAD
EEMEGTSSKN KQLRNDFKLV ENILAKRLLI LPQEEDYGFD IEEKNKAVVV KTVQRGSLAE
VAGLQVGRKI YSINEDLVFL RPFSEVESIL NQSFCSRRPL RLLVATKAKE IIKIPDQPDT
LCFQIHGAAP PYVYAVGRGS EAMAAGLCAG QCILKVNGSN VMNDGAPEVL DHFQAFRSRR
EEALGLYQWI YHTHEDAQEA RASQEAASED PSGEQAQEED QPDSAFPLLS LGPRLSLCED
SPMVSLTVDN VHLEHGVVYE YVSTAGVRCH VLEKIVEPRG CFGLTAKILE AFAADDSVFV
ENCGRLMALS SAIVTMPHFE FRNICDTKLE SIGQRIACYQ EFAAQLKSRV SPPFKQAPLE
PHPLCGLDFC PTNCHINLME VSYPKTTPSV GRSFSIRFGR KPSLIGLDPE QGHLNPMSYT
QHCITTMAAP SWKCLPAEEG DPQGQGLHDG SFGPEDRGLS FLLKQEDREI QDAYLQLFTK
LDVALKEMKQ YVTQINRLLS TITEPTSGGS CDASLAEEAS SLPLVSEESE MDRSDHGGIK
KVCFKVAEED QEDSGHDTMS YRDSYSECNS NRDSVLSYTS VRSNSSYLGS DEMGSGDELP
CDMRIPSDKQ DKLHGCLEHL FNQVDSINAL LKGPVMSRAF EETKHFPMNH SLQEFKQKEE
CTIRGRSLIQ ISIQEDPWNL PNSIKTLVDN IQRYVEDGKN QLLLALLKCT DTELQLRRDA
IFCQALVAAV CTFSEQLLAA LGYRYNNNGE YEESSRDASR KWLEQVAATG VLLHCQSLLS
PAAVKEERTM LEDIWVTLSE LDNVTFSFKQ LDENYVANTN VFYHIEGSRQ ALKVIFYLDS
YHFSKLPSRL EGGASLRLHT ALFTKALENV EGLLSPGSQA AEDLQQEINA QSLEKVQQYY
RKLRAFYLER SNLPTDASTT AVKIDQLIRP INALDELCRL MKSFVHPKPG AAGSVGAGLI
PISSELCYRL GACQMVMCGT GMQRSTLSVS LEQAAILARS HGLLPKCIMQ ATDIMRKQGP
RVEILAKNLR VKDQMPQGAP RLYRLCQPPV DGDL
//
