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Database: UniProt
Entry: A0A2K5MZG5_CERAT
LinkDB: A0A2K5MZG5_CERAT
Original site: A0A2K5MZG5_CERAT 
ID   A0A2K5MZG5_CERAT        Unreviewed;       374 AA.
AC   A0A2K5MZG5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE            EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000030586.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000030586.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC         and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC         residue protein attached to proteins as an intracellular targeting
CC         signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC   -!- SIMILARITY: Belongs to the peptidase C19 family. USP12/USP46 subfamily.
CC       {ECO:0000256|ARBA:ARBA00038282}.
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DR   AlphaFoldDB; A0A2K5MZG5; -.
DR   STRING; 9531.ENSCATP00000030586; -.
DR   Ensembl; ENSCATT00000054849.1; ENSCATP00000030586.1; ENSCATG00000038452.1.
DR   GeneTree; ENSGT00940000153284; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000038452; Expressed in frontal cortex and 12 other cell types or tissues.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   CDD; cd02663; Peptidase_C19G; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   PANTHER; PTHR24006:SF647; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 12; 1.
DR   Pfam; PF00443; UCH; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..374
FT                   /note="ubiquitinyl hydrolase 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014416732"
FT   DOMAIN          43..373
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
FT   REGION          149..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   374 AA;  43464 MW;  5742F6AC09A92561 CRC64;
     FCLLIFLLSF LSFCTEQKRC GANASALEKE IGPEQFPVNE HYFGLVNFGN TCYCNSVLQA
     LYFCRPFREK VLAYKSQPRK KESLLTCLAD LFHSIATQKK KVGVIPPKKF ITRLRKENEL
     FDNYMQQDAH EFLNYLLNTI ADILQEERKQ EKQNGRLPNG NIDNENNNST PDPTWVHEIF
     QGTLTNETRC LTCETISSKD EDFLDLSVDV EQNTSITHCL RGFSNTETLC SEYKYYCEEC
     RSKQEAHKRM KVKKLPMILA LHLKRFKYMD QLHRYTKLSY RVVFPLELRL FNTSGDATNP
     DRMYDLVAVV VHCGSGPNRG HYIAIVKSHD FWLLFDDDIV EKIDAQAIEE FYGLTSDISK
     NSESGYILFY QSRD
//
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