ID A0A2K5MZG5_CERAT Unreviewed; 374 AA.
AC A0A2K5MZG5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000030586.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000030586.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family. USP12/USP46 subfamily.
CC {ECO:0000256|ARBA:ARBA00038282}.
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DR AlphaFoldDB; A0A2K5MZG5; -.
DR STRING; 9531.ENSCATP00000030586; -.
DR Ensembl; ENSCATT00000054849.1; ENSCATP00000030586.1; ENSCATG00000038452.1.
DR GeneTree; ENSGT00940000153284; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000038452; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR CDD; cd02663; Peptidase_C19G; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF647; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 12; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..374
FT /note="ubiquitinyl hydrolase 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014416732"
FT DOMAIN 43..373
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 149..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 374 AA; 43464 MW; 5742F6AC09A92561 CRC64;
FCLLIFLLSF LSFCTEQKRC GANASALEKE IGPEQFPVNE HYFGLVNFGN TCYCNSVLQA
LYFCRPFREK VLAYKSQPRK KESLLTCLAD LFHSIATQKK KVGVIPPKKF ITRLRKENEL
FDNYMQQDAH EFLNYLLNTI ADILQEERKQ EKQNGRLPNG NIDNENNNST PDPTWVHEIF
QGTLTNETRC LTCETISSKD EDFLDLSVDV EQNTSITHCL RGFSNTETLC SEYKYYCEEC
RSKQEAHKRM KVKKLPMILA LHLKRFKYMD QLHRYTKLSY RVVFPLELRL FNTSGDATNP
DRMYDLVAVV VHCGSGPNRG HYIAIVKSHD FWLLFDDDIV EKIDAQAIEE FYGLTSDISK
NSESGYILFY QSRD
//