ID A0A2K5MZJ3_CERAT Unreviewed; 1861 AA.
AC A0A2K5MZJ3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 7 {ECO:0000313|Ensembl:ENSCATP00000030616.1};
GN Name=TRPM7 {ECO:0000313|Ensembl:ENSCATP00000030616.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000030616.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000030616.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR629601-3};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR629601-3};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSCATT00000054879.1; ENSCATP00000030616.1; ENSCATG00000038396.1.
DR GeneTree; ENSGT00940000157091; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000038396; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR CDD; cd16971; Alpha_kinase_ChaK1_TRMP7; 1.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029601; TRPM7_a-kinase_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF8; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 7; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR629601-2};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR629601-3};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR629601-2};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568};
KW Zinc {ECO:0000256|PIRSR:PIRSR629601-3}.
FT TRANSMEM 757..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 855..877
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 956..975
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 996..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1077..1100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1590..1820
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
FT REGION 543..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1832..1861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1839..1861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1763
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR629601-1"
FT BINDING 1620
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR629601-2"
FT BINDING 1644
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR629601-2"
FT BINDING 1716
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR629601-2"
FT BINDING 1749
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR629601-3"
FT BINDING 1765
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR629601-2"
FT BINDING 1773
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR629601-2"
FT BINDING 1790..1796
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR629601-2"
FT BINDING 1806
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR629601-3"
FT BINDING 1808
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR629601-3"
FT BINDING 1812
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR629601-3"
SQ SEQUENCE 1861 AA; 212363 MW; 529B8C830D955205 CRC64;
SQKSWIESTL TKRECIYIIP SSKDPHRCLP GCQICQQLVR CFCGRLVKQH ACFTASLAMK
YSDVKLGDHF NQAIEEWSVE KHTEQSPTDA YGVINFQGGS HSYRAKYVRL SYDTKPEVIL
QLLLKEWQME LPKLVISVHG GMQKFELHPR IKQLLGKGLI KAAVTTGAWI LTGGVNTGVA
KHVGDALKEH ASRSSRKICT IGIAPWGVIE NRNDLVGRDV VAPYQTLLNP LSKLNVLNNL
HSHFILVDDG TVGKYGAEVR LRRELEKTIN QQRIHARIVQ GVPVVALIFE GGPNVILTVL
EYLQESPPVP VVVCEGTGRA ADLLAYIHKQ TEEGGNLPDA AEPDIISTIK KTFNFGQNEA
VHLFQTLMEC MKRKELITVF HIGSDEHQDI DVAILTALLK GTNASAFDQL ILTLAWDRVD
IAKNHVFVYG QQWLVGSLEQ AMLDALVMDR VAFVKLLIEN GVSMHKFLTI PRLEELYNTK
QGPTNPMLFH LVRDVKQGNL PPGYKITLID IGLVIEYLMG GTYRCTYTRK RFRLIYNSLG
GNNRRSGRNT SSSTPQLRKS HESFGNRADK KEKMRHNHFI KTAQPYRPKI DTVVEEGKKK
RTKDEIVDID DPETKRFPYP LNELLIWACL MKRQVMARFL WQHGEESMAK ALVACKIYRS
MAYEAKQSDL VDDTSEELKQ YSNDFGQLAV ELLEQSFRQD ETMAMKLLTY ELKNWSNSTC
LKLAVSSRLR PFVAHTCTQM LLSDMWMGRL NMRKNSWYKV ILSILVPPAI LLLEYKTKAE
MSHIPQSQDA HQMTMDDSEN NFQNITEEIP MEVFKEVRIL DSNEGKNEME IQIKSKKLPI
TRKFYAFYHA PIVKFWFNTL AYLGFLMLYT FVVLVQMEQL PSVQEWIVIA YIFTYAIEKV
REIFMSEAGK VNQKIKVWFS DYFNISDTIA IISFFIGFGL RFGAKWNFAN AYDNHVFVAG
RLIYCLNIIF WYVRLLDFLA VNQQAGPYVM MIGKMVANMF YIVVIMALVL LSFGVPRKAI
LYPHEAPSWT LAKDIVFHPY WMIFGEVYAY EIDVCANDSV IPQICGPGTW LTPFLQAVYL
FVQYIIMVNL LIAFFNNVYL QVKAISNIVW KYQRYHFIMA YHEKPVLPPP LIILSHIVSL
FCCICKRRKK DKTSDGPKLF LTEEDQKKLH DFEEQCVEMY FNEKDDKFHS GSEERIRVTF
ERVEQMCIQI KEVGDRVNYI KRSLQSLDSQ IGHLQDLSAL TVDTLKTLTA QKASEASKVH
NEITRELSIS KHLAQNLIDD GPVRPSVWKK HSVVNTLSSS VPQGDLESNN PFLCNILMKD
DKDPQCNIFG QDLPAIPQRK EFNFPEAGSS SGALFPSAGS PPELRQRLHG VELLKIFNKN
QKLGSSSNSI PHLSSPPTKF FVSTPSQPSC KSHLETGTKD QETVCSKAAE GDNIEFGAFV
GHRDSMDLQR FKETSNKIKE ILFVIQLFSN CIYVQYLQNN NTSEKTLKRV NSLAGFTDCH
RTSIPLHSKQ AEKISRRPST EDTHEVDSKA ALIPVCLTSP FKPAMDTNYY YSAVERNNLM
RLSQSIPFTP VPPRGEPVTV YRLEESSPNI LNNSMSSWSQ LGLCAKIEFL SKEEMGGGLR
RAVKVQCTWS EHDILKSGHL YIIKSFLPEV VNTWSSIYKE DTVLHLCLRE IQQQRAAQKL
TFAFNQMKPK SIPYSPRFLE VFLLYCHSAG QWFAVEECMT GEFRKYNNNN GDEIIPTNTL
EEIMLAFSHW TYEYTRGELL VLDLQGVGEN LTDPSVIKAE EKRSCDMVFG PANLGEDAIK
NFRAKHHCNS CCRKLKLPDL KRNDYTPDKI IFPQDEPSDL NLQPGNSTKE SESTNSVRLM
L
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