ID A0A2K5N2E8_CERAT Unreviewed; 1170 AA.
AC A0A2K5N2E8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Folliculin interacting protein 2 {ECO:0000313|Ensembl:ENSCATP00000031668.1};
GN Name=FNIP2 {ECO:0000313|Ensembl:ENSCATP00000031668.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000031668.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000031668.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the FNIP family.
CC {ECO:0000256|ARBA:ARBA00007541}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011941919.1; XM_012086529.1.
DR AlphaFoldDB; A0A2K5N2E8; -.
DR STRING; 9531.ENSCATP00000031668; -.
DR Ensembl; ENSCATT00000055934.1; ENSCATP00000031668.1; ENSCATG00000038943.1.
DR GeneID; 105597873; -.
DR KEGG; caty:105597873; -.
DR CTD; 57600; -.
DR GeneTree; ENSGT00390000009391; -.
DR OrthoDB; 2725349at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000038943; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1990877; C:FNIP-folliculin RagC/D GAP; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042030; F:ATPase inhibitor activity; IEA:Ensembl.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:Ensembl.
DR InterPro; IPR037545; DENN_FNIP1/2.
DR InterPro; IPR028086; FNIP_C_dom.
DR InterPro; IPR026156; FNIP_fam.
DR InterPro; IPR028085; FNIP_mid_dom.
DR InterPro; IPR028084; FNIP_N_dom.
DR PANTHER; PTHR21634:SF11; FOLLICULIN-INTERACTING PROTEIN 2; 1.
DR PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR Pfam; PF14638; FNIP_C; 1.
DR Pfam; PF14637; FNIP_M; 1.
DR Pfam; PF14636; FNIP_N; 1.
DR PRINTS; PR02073; FOLLICULNIP1.
DR PROSITE; PS51836; DENN_FNIP12; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 65..1161
FT /note="UDENN FNIP1/2-type"
FT /evidence="ECO:0000259|PROSITE:PS51836"
FT REGION 637..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1170 AA; 128400 MW; 2D998A6E0D9CA785 CRC64;
MCGGTAKTTN QPGNWQDSAR CVSDAVPGAG RIYRALLCTK IKKHAGVDRS TDHTELDNSW
SCSEFDLNEI RLIVYQDCDR RGRQVLFDSK AVQKIEEVTA QKTEDVPIKI SAKCCQGSSS
VSSVSSSSSS SISFHSSSGG SSHHAKEQLP KYQYTRPASD VNMLGEMMFG SVAMSYKGST
LKIHYIRSPP QLMISKVFSA RMGSFCGSTN NLQDSFEYIN QDPNLGKLNT NQNSLGPCRT
GSNLGLLQAC SSKLLQGVAE GGPLRLTRSA SFFAAHSTPV DMPSRGQNED RDSGIARSAS
LSSLLITPFP SPSSSTSSSS SYQRRWLRSQ TTSLENGIIP RRSTDETFSL AEETCSSNPS
MVRRKKIAIS IIFSLCEKEE AQRNFQDFFF SHFPLFESHM NRLKSAIEKA MISCRKIAES
SLRVQFYVSR VMEALGEFRG TIWNLYSVPR IAEPVWLTMM SGTLEKNQLC QRFLKEFTLL
IEQINKNQFF AALLTAVLTY HLAWVPTVMP VDHPPIKAFS EKRTSQSVNM LAKTHPYNPL
WAQLGDLYGA IGSPVRLTRT VVVGKQKDLV QRILYVLTYF LRCSELQENQ LTWSGNHSEG
DQVLNGSKII TALEKGEVEE SEYVVVTVRN EPALVPPILP PTAAERQNPW PAGFPESPED
TDSRDLVLKP DKEANRRPEQ GFEACSTGCQ GPASGASWKP QNAFCGNEKN KEVPQDGSSR
LPSCEVLGAG MKMDQQAVCE PLKVEMSTRL PDRSVAWPCP DRHLWEKPPI EKVTFQIGSS
TSPESDFESR MKKMEERMKA CGPSLEAREA ADTAQDPQIS RSPFKPGFQE NVRCPQNRSS
EGDEGESDKG FAEDRGSRND TAADAAGQLS HAADLGAASH RVAGTAPGRL EAATGLYVKA
EEGPVLEPVA ASCVQRGPGL VAPANIPCGD DNKKANFRTE GDIPRNESSD SALGDSDDEA
CTSAMLDLGH GGDRTGGSLE VELPLPRSQS ISTQNVRNFG RSLLAGYCPT YMPDLVLHGT
GSDEKLKQCL VADLVHTVHH PVLDEPIAEA VCIIADTDKW SVQVATSQRK VTDNMKLGQD
VLVSSQVSSL LQSILQLYKL HLPADFCIMH LEDRLQEMYL KSKMLSEYLR GHTRVHVKEL
GVVLGIESND LPLLTAIAST HSPYVAQILL
//
