ID A0A2K5N379_CERAT Unreviewed; 783 AA.
AC A0A2K5N379;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Colony stimulating factor 3 receptor {ECO:0000313|Ensembl:ENSCATP00000031780.1};
GN Name=CSF3R {ECO:0000313|Ensembl:ENSCATP00000031780.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000031780.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000031780.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR AlphaFoldDB; A0A2K5N379; -.
DR Ensembl; ENSCATT00000056046.1; ENSCATP00000031780.1; ENSCATG00000038990.1.
DR GeneTree; ENSGT00940000158915; -.
DR OMA; SYCSIPR; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000038990; Expressed in lung and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF103; GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..783
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014318299"
FT TRANSMEM 626..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 233..332
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 334..430
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 431..528
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 530..623
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 735..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 86755 MW; 9E514CBE673C3F3F CRC64;
MARLRTCSLT WAALIILLLP RSLEECGHIS VSAPIVHLGD PITASCIIKQ NCSHLDLEPQ
ILWRLGAELQ PGGRQQRLSD GSQQSTITLP HLNHTRAFLS CCLNWGNSLQ ILDQVELRAG
YPPAVPRNLS CLMNLTTSSL ICQWEPGPET HLPTSFTLKS FKSRGNCQTQ GDSIMDCVPE
DGQSHCSIPR RHLLLYQNMG IWVQAENALG TSMSPQLCLE PMDVVKLEPP MLRTMDPSPE
AAPPQAGCLQ LCWEPWQPAL HINQKCELRH KPQSGEASWA LVGPLPLEAL RYELCGLLPA
TAYTLQIRCI RWPLPGHWSN WSPSLELRTT ERAPAVRLNT WWRQRQLDPR TVQLFWKPVP
LEEDSGQIQG YVVSWRPSGQ AGAILPLCNT TELSCTFPLP SEAQEVALVA YNSAGTSCPT
PVVFSESRGP ALTRLHAMAR DPHSLWVGWE PPSPWPRGYV IEWGLSSPST SNSNKTWRME
QNGSATGFLL QENIRPFQLY EITVTPLYQD AMGPSQHVYA YSQEMAPRHA PELHLKHIGK
TWAQLEWVPE PPELGKSPLT HYTIFWTNAQ NQSFSTILNA SSRGFVLHGL EPASLYHIHL
MAASQAGATN STVLTLMTLI PEGSELHILL GLFGLLLLLS CLCGTAWLCC SPSRKNPLWP
SVPDPAHSSL GSWVPTIMEE EAFQLPGLGM PPITKLTVLE EDEKKPLPWE SHDSSETCGL
PTLVQTYVLQ GDLRAASAQP QSQSGTSNQA GPPRQSSYFK DQIMLHPAPP NGLLYLFPIT
SVL
//
