UniProt: A0A2K5N3A7

Database: UniProt
Entry: A0A2K5N3A7_CERAT

LinkDB:  A0A2K5N3A7_CERAT 
Original site:  A0A2K5N3A7_CERAT

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Ontology (52)   
   GO (52)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (9)   
   InterPro (6)   
   Pfam (3)   
All databases (67)   

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ID   A0A2K5N3A7_CERAT        Unreviewed;       743 AA.
AC   A0A2K5N3A7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=N-acetyl-alpha-glucosaminidase {ECO:0000313|Ensembl:ENSCATP00000031982.1};
GN   Name=NAGLU {ECO:0000313|Ensembl:ENSCATP00000031982.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000031982.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000031982.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
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DR   RefSeq; XP_011902089.1; XM_012046699.1.
DR   AlphaFoldDB; A0A2K5N3A7; -.
DR   STRING; 9531.ENSCATP00000031982; -.
DR   Ensembl; ENSCATT00000056249.1; ENSCATP00000031982.1; ENSCATG00000039094.1.
DR   GeneID; 105579671; -.
DR   KEGG; caty:105579671; -.
DR   CTD; 4669; -.
DR   GeneTree; ENSGT00390000005900; -.
DR   OMA; YGQPFVW; -.
DR   OrthoDB; 1112009at2759; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000039094; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0043202; C:lysosomal lumen; IEA:Ensembl.
DR   GO; GO:0004561; F:alpha-N-acetylglucosaminidase activity; IEA:Ensembl.
DR   GO; GO:0030534; P:adult behavior; IEA:Ensembl.
DR   GO; GO:0042982; P:amyloid precursor protein metabolic process; IEA:Ensembl.
DR   GO; GO:0035909; P:aorta morphogenesis; IEA:Ensembl.
DR   GO; GO:0048143; P:astrocyte activation; IEA:Ensembl.
DR   GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR   GO; GO:0055013; P:cardiac muscle cell development; IEA:Ensembl.
DR   GO; GO:0044242; P:cellular lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0021680; P:cerebellar Purkinje cell layer development; IEA:Ensembl.
DR   GO; GO:0032963; P:collagen metabolic process; IEA:Ensembl.
DR   GO; GO:1904390; P:cone retinal bipolar cell differentiation; IEA:Ensembl.
DR   GO; GO:0007028; P:cytoplasm organization; IEA:Ensembl.
DR   GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
DR   GO; GO:0003158; P:endothelium development; IEA:Ensembl.
DR   GO; GO:0035640; P:exploration behavior; IEA:Ensembl.
DR   GO; GO:0001573; P:ganglioside metabolic process; IEA:Ensembl.
DR   GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR   GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
DR   GO; GO:0030200; P:heparan sulfate proteoglycan catabolic process; IEA:Ensembl.
DR   GO; GO:0030201; P:heparan sulfate proteoglycan metabolic process; IEA:Ensembl.
DR   GO; GO:0030202; P:heparin metabolic process; IEA:Ensembl.
DR   GO; GO:0042445; P:hormone metabolic process; IEA:Ensembl.
DR   GO; GO:0060119; P:inner ear receptor cell development; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:0060173; P:limb development; IEA:Ensembl.
DR   GO; GO:0001889; P:liver development; IEA:Ensembl.
DR   GO; GO:0045475; P:locomotor rhythm; IEA:Ensembl.
DR   GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR   GO; GO:0035633; P:maintenance of blood-brain barrier; IEA:Ensembl.
DR   GO; GO:0014004; P:microglia differentiation; IEA:Ensembl.
DR   GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
DR   GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
DR   GO; GO:0003183; P:mitral valve morphogenesis; IEA:Ensembl.
DR   GO; GO:0061744; P:motor behavior; IEA:Ensembl.
DR   GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IEA:Ensembl.
DR   GO; GO:0021675; P:nerve development; IEA:Ensembl.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR   GO; GO:0097696; P:receptor signaling pathway via STAT; IEA:Ensembl.
DR   GO; GO:0034285; P:response to disaccharide; IEA:Ensembl.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0009611; P:response to wounding; IEA:Ensembl.
DR   GO; GO:0046548; P:retinal rod cell development; IEA:Ensembl.
DR   GO; GO:1904389; P:rod bipolar cell differentiation; IEA:Ensembl.
DR   GO; GO:0097577; P:sequestering of iron ion; IEA:Ensembl.
DR   GO; GO:0006801; P:superoxide metabolic process; IEA:Ensembl.
DR   GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR   GO; GO:0099022; P:vesicle tethering; IEA:Ensembl.
DR   Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 1.20.120.670; N-acetyl-b-d-glucoasminidase; 1.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR029018; Hex-like_dom2.
DR   InterPro; IPR007781; NAGLU.
DR   InterPro; IPR024732; NAGLU_C.
DR   InterPro; IPR024240; NAGLU_N.
DR   InterPro; IPR024733; NAGLU_tim-barrel.
DR   PANTHER; PTHR12872; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   PANTHER; PTHR12872:SF1; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   Pfam; PF05089; NAGLU; 1.
DR   Pfam; PF12972; NAGLU_C; 1.
DR   Pfam; PF12971; NAGLU_N; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..743
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014477556"
FT   DOMAIN          30..116
FT                   /note="Alpha-N-acetylglucosaminidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12971"
FT   DOMAIN          130..465
FT                   /note="Alpha-N-acetylglucosaminidase tim-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF05089"
FT   DOMAIN          474..732
FT                   /note="Alpha-N-acetylglucosaminidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12972"
SQ   SEQUENCE   743 AA;  82142 MW;  3656A8CEEEE4FD92 CRC64;
     MVAVAVAAAV GVLLLAGAGD AAGDEAREAA AVRALVARLL GPGPAADFSV SVERALATKP
     GLDTYSLGGG GAARVRVRGS TGVAAAAGLH RYLRDFCGCH VAWSGSQLRL PRPLPAVPGE
     LTEATPNRYR YYQNVCTQSY SFVWWDWARW EREIDWMALN GINLALAWSG QEAIWQRVYL
     ALGLTQTEIN EFFTGPAFLA WGRMGNLHTW DGPLPPSWHI KQLYLQHRVL DRMRSFGMTP
     VLPAFAGHVP EAVTRVFPQV NVTKMGSWGH FNCSYSCSFL LAPEDPMFPV IGSLFLRELV
     KEFGTDHIYG ADTFNEMQPP SSAPSYLAAA TTAVYEAMIA VDTEAVWLLQ GWLFQHQPQF
     WGPAQIGAVL GAVPRGRLLV LDLFAESQPV YTRTASFQGQ PFIWCMLHNF GGNHGLFGAL
     EAVNGGPEAA RLFPNSTMVG TGMAPEGISQ NEVVYSLMAE LGWRKDPVPD LAAWVTNFAA
     QRYGVSHPDA GAAWRLLLRS VYNCSGEACR GHNRSPLVRR PSLQMNTSVW YNRSSVFEAW
     RLLLTSAPSL AASPAFRYDL LDLTRQAVQE LVSLYYEEAR SAYLSKELTS LLRAGGVLAY
     ELLPALDELL ASDSRFLLGS WLEQARAAAV SEAEADFYEQ NSRYQLTLWG PEGNILDYAN
     KQLAGLVANY YTPRWRLFLE ALADSVAQGI PFQQHQFDKN AFQLEQAFVL SKQRYPSQPR
     GDTVDLAKKI FLKYYPRWVA GSW
//

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