GenomeNet

Database: UniProt
Entry: A0A2K5N695_CERAT
LinkDB: A0A2K5N695_CERAT
Original site: A0A2K5N695_CERAT 
ID   A0A2K5N695_CERAT        Unreviewed;       692 AA.
AC   A0A2K5N695;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   10-APR-2019, entry version 11.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCATP00000032855};
GN   Name=PCSK9 {ECO:0000313|Ensembl:ENSCATP00000032855};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000032855, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000032855, ECO:0000313|Proteomes:UP000233060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y., Hughes D.S., Murali S., Raveendran M., Korchina V., Wang M.,
RA   Jhangiani S., Bandaranaike D., Bellair M., Blankenburg K., Chao H.,
RA   Dahdouli M., Dinh H., Doddapaneni H., English A., Firestine M.,
RA   Gross S., Hernandez B., Javaid M., Jayaseelan J., Jones J., Joshi V.,
RA   Khan Z., Kovar C., Lee S., Newsham I., Nguyen L., Okwuonu G.,
RA   Ongeri F., Osuji N., Pu L.-L., Puazo M., Qu C., Quiroz J., Raj R.,
RA   Reid J.G., Santibanez J., Scheel M., Sexton D., Shah N., Skinner E.,
RA   Vee V., Wu Y., Han Y., Muzny D.M., Richards S., Worley K.C.,
RA   Rogers J., Gibbs R.A.;
RT   "Sooty reference genome and diversity panel.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCATP00000032855}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS01087990}.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|SAAS:SAAS01077246}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_011937909.1; XM_012082519.1.
DR   RefSeq; XP_011937910.1; XM_012082520.1.
DR   RefSeq; XP_011937911.1; XM_012082521.1.
DR   Ensembl; ENSCATT00000057126; ENSCATP00000032855; ENSCATG00000039450.
DR   GeneID; 105595991; -.
DR   CTD; 255738; -.
DR   GeneTree; ENSGT00490000043472; -.
DR   OrthoDB; 921536at2759; -.
DR   Proteomes; UP000233060; Whole Genome Shotgun Assembly.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:1990667; C:PCSK9-AnxA2 complex; IEA:Ensembl.
DR   GO; GO:1990666; C:PCSK9-LDLR complex; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0034185; F:apolipoprotein binding; IEA:Ensembl.
DR   GO; GO:0034190; F:apolipoprotein receptor binding; IEA:Ensembl.
DR   GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:Ensembl.
DR   GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0030547; F:receptor inhibitor activity; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:Ensembl.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:Ensembl.
DR   GO; GO:0034189; F:very-low-density lipoprotein particle binding; IEA:Ensembl.
DR   GO; GO:0070326; F:very-low-density lipoprotein particle receptor binding; IEA:Ensembl.
DR   GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR   GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
DR   GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:Ensembl.
DR   GO; GO:0001889; P:liver development; IEA:Ensembl.
DR   GO; GO:0032802; P:low-density lipoprotein particle receptor catabolic process; IEA:Ensembl.
DR   GO; GO:0007041; P:lysosomal transport; IEA:Ensembl.
DR   GO; GO:0010989; P:negative regulation of low-density lipoprotein particle clearance; IEA:Ensembl.
DR   GO; GO:1905596; P:negative regulation of low-density lipoprotein particle receptor binding; IEA:Ensembl.
DR   GO; GO:1905598; P:negative regulation of low-density lipoprotein receptor activity; IEA:Ensembl.
DR   GO; GO:0001920; P:negative regulation of receptor recycling; IEA:Ensembl.
DR   GO; GO:1905601; P:negative regulation of receptor-mediated endocytosis involved in cholesterol transport; IEA:Ensembl.
DR   GO; GO:2000650; P:negative regulation of sodium ion transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
DR   GO; GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
DR   GO; GO:0032805; P:positive regulation of low-density lipoprotein particle receptor catabolic process; IEA:Ensembl.
DR   GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0002092; P:positive regulation of receptor internalization; IEA:Ensembl.
DR   GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR   GO; GO:0006641; P:triglyceride metabolic process; IEA:Ensembl.
DR   CDD; cd04077; Peptidases_S8_PCSK9_Proteinase; 1.
DR   Gene3D; 3.30.70.80; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR041254; PCSK9_C.
DR   InterPro; IPR041052; PCSK9_C2.
DR   InterPro; IPR041051; PCSK9_C3.
DR   InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF18459; PCSK9_C1; 1.
DR   Pfam; PF18464; PCSK9_C2; 1.
DR   Pfam; PF18463; PCSK9_C3; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; SSF52743; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000233060};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01077244};
KW   Protease {ECO:0000256|SAAS:SAAS01099369};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Secreted {ECO:0000256|SAAS:SAAS01087992};
KW   Serine protease {ECO:0000256|SAAS:SAAS01099373};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31    692       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014394011.
FT   DOMAIN       77    149       Inhibitor I9. {ECO:0000259|Pfam:PF05922}.
FT   DOMAIN      182    417       Peptidase S8. {ECO:0000259|Pfam:PF00082}.
FT   DOMAIN      450    531       PCSK9_C1. {ECO:0000259|Pfam:PF18459}.
FT   DOMAIN      535    600       PCSK9_C2. {ECO:0000259|Pfam:PF18464}.
FT   DOMAIN      602    682       PCSK9_C3. {ECO:0000259|Pfam:PF18463}.
SQ   SEQUENCE   692 AA;  74486 MW;  C92B1DEAD30F9B00 CRC64;
     MGTVSSRRSW WPLPLPLLLL LLLGPAGARA QEDEDGDYEE LVLALRSEED GLADAPEHGA
     TATFHRCAKD PWRLPGTYVV VLKEETHRSQ SERTARRLQA QAARRGYLTK ILHVFHHLLP
     GFLVKMSGDL LELALKLPHV DYIEEDSSVF AQSIPWNLER ITPARYRADE YQPPKGGSLV
     EVYLLDTSIQ SDHREIEGRV MVTDFESVPE EDGTRFHRQA SKCDSHGTHL AGVVSGRDAG
     VAKGAGLRSL RVLNCQGKGT VSGTLIGLEF IRKSQLVQPV GPLVVLLPLA GGYSRVFNAA
     CQRLARAGVV LVTAAGNFRD DACLYSPASA PEVITVGATN AQDQPVTLGT LGTNFGRCVD
     LFAPGEDIIG ASSDCSTCFV SRSGTSQAAA HVAGIAAMML SAEPELTLAE LRQRLIHFSA
     KDVINEAWFP EDQRVLTPNL VAALPPSTHR AGWQLFCRTV WSAHSGPTRM ATAVARCAPD
     EELLSCSSFS RSGKRRGERI EAQGGKRVCR AHNAFGGEGV YAIARCCLLP QVNCSVHTAP
     PAGASMGTRV HCHQQGHVLT GCSSHWEVED LGTHKPPVLR PRGQPNQCVG HREASIHASC
     CHAPGLECKV KEHGIPAPQE QVIVACEDGW TLTGCSALPG TSHVLGAYAV DNTCVVRSRD
     ISTTGSTSEE AVAAVAICCR SRHLVQASQE LQ
//
DBGET integrated database retrieval system