ID A0A2K5N8R2_CERAT Unreviewed; 334 AA.
AC A0A2K5N8R2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=E2F transcription factor 3 {ECO:0000313|Ensembl:ENSCATP00000033859.1};
GN Name=E2F3 {ECO:0000313|Ensembl:ENSCATP00000033859.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000033859.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000033859.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR RefSeq; XP_011886813.1; XM_012031423.1.
DR AlphaFoldDB; A0A2K5N8R2; -.
DR SMR; A0A2K5N8R2; -.
DR Ensembl; ENSCATT00000058134.1; ENSCATP00000033859.1; ENSCATG00000039889.1.
DR GeneID; 105572601; -.
DR CTD; 1871; -.
DR GeneTree; ENSGT00940000155115; -.
DR OMA; WMGCNLS; -.
DR OrthoDB; 1761at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000039889; Expressed in bone marrow and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14660; E2F_DD; 1.
DR Gene3D; 6.10.250.540; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR032198; E2F_CC-MB.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF44; TRANSCRIPTION FACTOR E2F3; 1.
DR Pfam; PF16421; E2F_CC-MB; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 47..112
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 334 AA; 37054 MW; 11C1E9B0CA4F2008 CRC64;
MPLQQQAKRR LELGESGHQY LSDGLKTPKG KGRAALRSPD SPKKKTRYDT SLGLLTKKFI
QLLSQSPDGV LDLNKAAEVL KVQKRRIYDI TNVLEGIHLI KKKSKNNVQW MGCSLSEDGG
MLAQCQGLSK EVTELSQEEK KLDELIQSCT LDLKLLTEDS ENQRLAYVTY QDIRKISGLK
DQTVIVVKAP PETRLEVPDS IESLQIHLAS TQGPIEVYLC PEETETHSPM KTNNQDHNGN
IPKPTSKDLA STNSGHSDCS ISMGNLSPLA SPANLLQQTE DQIPSNLEGP FVNLLPPLLQ
EDYLLSLGEE EGISDLFDAY DLEKLPLVED FMCS
//
