ID A0A2K5N8U9_CERAT Unreviewed; 409 AA.
AC A0A2K5N8U9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Protrudin {ECO:0000256|ARBA:ARBA00015523};
DE AltName: Full=Zinc finger FYVE domain-containing protein 27 {ECO:0000256|ARBA:ARBA00032025};
GN Name=ZFYVE27 {ECO:0000313|Ensembl:ENSCATP00000033770.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000033770.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000033770.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, growth cone membrane
CC {ECO:0000256|ARBA:ARBA00004460}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004460}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004195}.
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DR RefSeq; XP_011906785.1; XM_012051395.1.
DR AlphaFoldDB; A0A2K5N8U9; -.
DR SMR; A0A2K5N8U9; -.
DR Ensembl; ENSCATT00000058044.1; ENSCATP00000033770.1; ENSCATG00000039847.1.
DR GeneID; 105581802; -.
DR CTD; 118813; -.
DR GeneTree; ENSGT00390000013298; -.
DR OrthoDB; 38671at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000039847; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032584; C:growth cone membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0071787; P:endoplasmic reticulum tubular network formation; IEA:InterPro.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd15723; FYVE_protrudin; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR042405; Protrudin.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14543; PROTRUDIN; 1.
DR PANTHER; PTHR14543:SF1; PROTRUDIN; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT TRANSMEM 64..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 342..408
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 45622 MW; C15829A7DE7850EC CRC64;
MQTSEREGSG PELSPSVMPE APLESPPFPT KSPAFDLFNL VLSYKRLEIY LEPLKDAGDG
VRYLLRWQMP LCSLLTCLGL NILFLTLNEG AWYSVGALMI SVPALLGYLQ EVCRARLPES
ELMRRKYHSV RQEDLQRVRL SRPEAVAEVK SFLIQLEAFL SRLCCTCEAA YRVLHWENPV
VSSQFYGALL GTVCMLYLLP LCWVLTLLNS TLFLGNVEFF RVVSEYRASL QQRMNPKQEE
HAFESPPPPD VGGKGGLMDS TPALTPTESL SSQDLTPGSV EEAEEAEPDE EFKDAIEEDD
EGVPCPAEDE LALQDNGFLS KNEVLRSKVS RLTERLRKRY PTNNFGNCTG CSATFSVLKK
RRSCSNCGNS FCSRCCSFKV PRSSMGATAP EAQRETVFVC ASCNQTLSK
//
