ID A0A2K5NB10_CERAT Unreviewed; 605 AA.
AC A0A2K5NB10;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Nuclear receptor subfamily 2 group C member 2 {ECO:0000313|Ensembl:ENSCATP00000034611.1};
GN Name=NR2C2 {ECO:0000313|Ensembl:ENSCATP00000034611.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000034611.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000034611.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000256|ARBA:ARBA00006421}.
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DR AlphaFoldDB; A0A2K5NB10; -.
DR Ensembl; ENSCATT00000058891.1; ENSCATP00000034611.1; ENSCATG00000040182.1.
DR GeneTree; ENSGT00940000158393; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000040182; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06952; NR_LBD_TR2_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR048246; NR2C1/2-like_LBD.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24083:SF48; NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 2; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 123..198
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 350..592
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 605 AA; 66366 MW; F4380DF80CADEC92 CRC64;
MTSPSPRIQI ISTDSAVASP QRIQGSEPAS GPLSVFTSLN KEKIVTDQQT GQKIQIVTAV
DASGSPKQQF ILTSPDGAGT GKVILASPET SSAKQLIFTT SDNLVPGRIQ VRLFGDLQTW
QVAALAKVIN QQTSGRHYGA VSCEGCKGFF KRSVRKNLTY SCRSNQDCII NKHHRNRCQF
CRLKKCLEMG MKMESVQSER KPFDVQREKP SNCAASTEKI YIRKDLRSPL IATPTFVADK
DGARQTGLLD PGMLVNIQQP LIREDGTVLL ATDSKAETSQ GALGTLANVV TSLANLSESL
NNGDTSEIQP EDQSASEITR AFDTLAKALN TTDSSSSPSL ADGIDTSGGG SIHVISRDQS
TPIIEVEGPL LSDTHVTFKL TMPSPMPEYL NVHYICESAS RLLFLSMHWA RSIPAFQALG
QDCNTSLVRA CWNELFTLGL AQCAQVMSLS TILAAIVNHL QNSIQEDKLS GDRIKQVMEH
IWKLQEFCNS MAKLDIDGYE YAYLKAIVLF SPDHPGLTST SQIEKFQEKA QMELQDYVQK
TYSEDTYRLA RILVRLPALR LMSSNITEEL FFTGLIGNVS IDSIIPYILK METAEYNGQI
TGASL
//
