ID A0A2K5NCV1_CERAT Unreviewed; 772 AA.
AC A0A2K5NCV1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=SIX homeobox 4 {ECO:0000313|Ensembl:ENSCATP00000035160.1};
GN Name=SIX4 {ECO:0000313|Ensembl:ENSCATP00000035160.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000035160.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000035160.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011917411.1; XM_012062021.1.
DR AlphaFoldDB; A0A2K5NCV1; -.
DR STRING; 9531.ENSCATP00000035160; -.
DR Ensembl; ENSCATT00000059441.1; ENSCATP00000035160.1; ENSCATG00000040466.1.
DR GeneID; 105586710; -.
DR CTD; 51804; -.
DR GeneTree; ENSGT00940000160820; -.
DR OMA; MCGEMEA; -.
DR OrthoDB; 5317763at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000040466; Expressed in skeletal muscle tissue and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR GO; GO:0061197; P:fungiform papilla morphogenesis; IEA:Ensembl.
DR GO; GO:0048699; P:generation of neurons; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0030238; P:male sex determination; IEA:Ensembl.
DR GO; GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
DR GO; GO:0051451; P:myoblast migration; IEA:Ensembl.
DR GO; GO:0061055; P:myotome development; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1902725; P:negative regulation of satellite cell differentiation; IEA:Ensembl.
DR GO; GO:0030910; P:olfactory placode formation; IEA:Ensembl.
DR GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0072107; P:positive regulation of ureteric bud formation; IEA:Ensembl.
DR GO; GO:0034504; P:protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0072095; P:regulation of branch elongation involved in ureteric bud branching; IEA:Ensembl.
DR GO; GO:0050678; P:regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR GO; GO:0008582; P:regulation of synaptic assembly at neuromuscular junction; IEA:Ensembl.
DR GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR GO; GO:0098528; P:skeletal muscle fiber differentiation; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR GO; GO:0061551; P:trigeminal ganglion development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR031701; SIX1_SD.
DR PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR PANTHER; PTHR10390:SF36; HOMEOBOX PROTEIN SIX4; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16878; SIX1_SD; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 221..272
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 223..273
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 82165 MW; 71EBEF4D843CD728 CRC64;
MIASAADIKQ ENGMESASEG QEAHREVAGG AAVGLSPPAP APFPLEPGDA ATAAARVSGE
EGAVATAAAG AAADQVQLHS ELLGRHHHAA AAAQTPLAFS PDHVACVCEA LQQGGNLDRL
ARFLWSLPQS DLLRGNESLL KARALVAFHQ GIYPELYSIL ESHSFESANH PLLQQLWYKA
RYTEAERARG RPLGAVDKYR LRRKFPLPRT IWDGEETVYC FKEKSRNALK ELYKQNRYPS
PAEKRHLAKI TGLSLTQVSN WFKNRRQRDR NPSETQSKSE SDGNPSTEDE SSKGHEDLSP
HPLSSSSDGI TNLSLSSHME PVYMQQIGNA KISLSSSGVL LNGSLVPAST SPVFLNGNSF
IQGPSGVILN GLNVGNTQAV ALNPPKMSSN IVSNGVSMTD ILGSTSQDVK EFKVLQSSAN
SAATTSYSPS VPVSFPGLIP SNEVKREGIQ TVASQDGGSV VTFTTPVQIN QYGIVQIPNS
GTNSQFLNGS IGFSPLQLPA VSVAASQGNI SVSSSTSDGS TFTSESATVQ QGKVFLSSLA
PSAVVYTVPN TSQTIGSVKQ EGLERSLVFS QLMPVNQNAQ VNANLSSENI SGSGLHPLAS
SLVNVSPTHN FSLSPPTLLN PTELNHDIAD SQPMSAPVAS KSTVTSVSNT NYATLQNCSL
ITGQDLLSVP MTQAALGEIV PTAEDQVGHP SPAVHQDFVQ EHRLVLQSVT NMKENFLPNS
ESKATSSLMM LDSKSKYVLD GMVDTVCEDL ETDKKELAKL QTVQLDEDMQ DL
//
