ID A0A2K5NDJ2_CERAT Unreviewed; 1373 AA.
AC A0A2K5NDJ2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=WRN {ECO:0000313|Ensembl:ENSCATP00000035400.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000035400.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000035400.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR RefSeq; XP_011900948.1; XM_012045558.1.
DR Ensembl; ENSCATT00000059682.1; ENSCATP00000035400.1; ENSCATG00000040557.1.
DR GeneID; 105579125; -.
DR CTD; 7486; -.
DR GeneTree; ENSGT00940000159168; -.
DR OMA; TSQDFGP; -.
DR OrthoDB; 5474026at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000040557; Expressed in bone marrow and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18017; DEXHc_RecQ3; 1.
DR CDD; cd06129; RNaseD_like; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029491; Helicase_HTH.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR PANTHER; PTHR13710:SF120; WERNER SYNDROME ATP-DEPENDENT HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF14493; HTH_40; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 530..696
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 721..872
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1123..1202
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 475..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..500
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1373 AA; 155337 MW; 0DB4214D1C58E8F9 CRC64;
MNEKKSETTS RQRKCPEWMN VQNKRCAVEE RKACVRKSVF EDDLPFLEFT GSIVYSYDAS
DCSFLSEDIR MSLSDGDVVG FDMEWPPLYN KGKLGKVALI QLCVSESKCY LFHISSMSVF
PQGLKMLLEN KAIKKAGVGI EGDQWKLLRD FDIKLKNFVE LTDVANKKLK CTETWSLSGL
VKHLLGKQLL KDKSIRCSNW SKFPLTEDQK LYAATDAYAG FIIYRNLEIL DDAVQRFAIN
KEEEILLSDM NKQLTSISEE VMDLAKHLPD AFSKLENPQR VSILLKDISE NLYSLRKMII
GSTNIETELR PSNNLNLLSF EDSTTGGVQQ KQIGEHKIFI NVEDETWDPT LDHLAKHGGE
DVLGNKVERK EDGFEEGVED NKLKENMERA CLMSLDITEH ELQILEQQAQ EKYLSDIAYK
STEHLSPTNN ENDTSYVIES DEDLEMEMLK SLENLNSGTV EPTHSKCLDM ERNLGLPTKE
EDDDENEANE EEEDDDKDSL LPAPNEEQVT CLKMYFGHSS FKPVQWKVIH SVLEERRDNV
AVMATGYGKS LCFQYPPVYV GKIGLVISPL ISLMEDQVLQ LKMSNIPTCF LGSAQSENVL
TDIKLGKYRI VYITPEYCSG NMGLLQQLEA DIGITLIAVD EAHCISEWGH DFRNSFRKLG
SLKTALPMVP IVALTATATS SIREDIVRCL NLRNPQIICT GFDRPNLYLE VRRKTGNILQ
DLQPFLVKTT SSHWEFEGPT IIYCPSRKMT EQVTAELRKL NLSCETYHAG MSFSRRKDVH
HRFVRDEIQC VIATIAFGMG INKADIRQVI HYGAPKEMES YYQEIGRAGR DGLQSSCHIL
WAPADINLNR HLLTEIRNEK FRLYKLKMMA KMEKYLHSSR CRRQIILSHF EDKQVQKASL
GITGTEKCCD NCRSRLGHCY SMDDSEDTSW DFGPQAFQLL SAVDILGEKF GIGLPILFLR
GSNSQRLADQ YRKHSLFGTG KDQTESWWKA FSRQLIIEGF LIEVSGSNKF IKICTLTKKG
RNWLRKANTE SQSLILQANE ELCPKKFLLP SSRTVSSGTK EHSYNQVPVE LTAEKKSNLE
KLYSYKPCDK VSSGSNISKK SIMVQAPEKS YSSSEPVISA QEQETQTVLY GKLVEARQKH
ANKMDVPPAI LATNKILVDM AKMRPTTVEN IKRIDGVSEG KAAMLAPLLE VIKHFCQTNS
VQTDLFSSTE PQEEQKTSLV AKNKICTLSQ SMAITYSLFQ EKKMPLKSIA ESRILPLMTI
GMHLSQAVKA GCPLDLERAG LTPEVQKIIA DVIRNPPVNS DMSKINLIRM LVPENIDTYL
IHMAIEILKH GTDSRLQPSC DVNKRRCFPS SEEISSSSKR SKEEGNNGVG AGK
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