ID A0A2K5NDR2_CERAT Unreviewed; 2081 AA.
AC A0A2K5NDR2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Dedicator of cytokinesis 9 {ECO:0000313|Ensembl:ENSCATP00000035556.1};
GN Name=DOCK9 {ECO:0000313|Ensembl:ENSCATP00000035556.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000035556.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000035556.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR Ensembl; ENSCATT00000059841.1; ENSCATP00000035556.1; ENSCATG00000040587.1.
DR GeneTree; ENSGT00940000155972; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000040587; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 185..292
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 651..829
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1616..2043
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 301..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2081 AA; 237957 MW; D809CE4C6A22116F CRC64;
MGCTTSVILF KGIRTVFERN CAYMCKQQGE NNALEYTAYN WTKEDSELLI SSWLAKPKLI
EPLDYENVIV QKKTQILNDC LREMLLFPYD DFQTAILRRQ GRYICSTVPA KAEEEAQSLF
VTECIKTYNS DWHLVNYKYE DYSGEFRQLP NKVVKLDKLP VHVYEVDEEV DKDEDAASLG
SQKGGITKHG WLYKGNMNSA ISVTMRSFKR RFFHLIQLGD GSYNLNFYKD EKISKEPKGS
IFLDSCMGVV QNNKVRRFAF ELKMQDKSSY LLAADSEVEM EEWITILNKI LQLNFEAAMQ
EKRNGDSHED DEQSKLEGSG SSLDSYLPEL AKSAREAEIK LKSESRVKLF YLDPDAQKLD
FSSAEPEVKP FEEKFGKRIL VKCNDLSFNL QCCVAENEEG PTTNVEPFFV TLSLFDIKYN
RKISADFHVD LNHFSVRQML ATTSPALMNG SGQSPSVLKG ILHEAAMQYP KQGIFSVTCP
HPDIFLVARI EKVLQGSITH CAEPYMKSSD SSKVAQKVLK NAKQACQRLG QYRMPFAWAA
RTLFKDASGN LDKNARFSAI YRQDSNKLSN DDMLKLLADF RKPEKMAKLP VILGNLDITI
DNVSSDFPNY VNSSYIPTKQ FETCSKTPIT FEVEEFVPCI PKHTQPYTIY TNHLYVYPKY
LKYDSQKSFA KARNIAICIE FKDSDEEDSQ PLKCIYGRPG GPVFTRSAFA AVLHHHQNPE
FYDEIKIELP TQLHEKHHLL LTFFHVSCDN SSKGSTKKRD VVETQVGYSW LPLLKDGRVV
TSEQHIPVSA NLPSGYLGYQ ELGMGRHYGP EIKWVDGGKP LLKISTHLVS TVYTQDQHLH
NFFQYCQKTE SGAQALGNEL VKYLKSLHAM EGHVMIAFLP TILNQLFRVL TRATQEEVAV
NVTRVIIHVV AQCHEEGLES HLRSYVKYAY KAEPYVASEY KTVHEELTKS MTTILKPSAD
FLTSNKLLKY SWFFFDVLIK SMAQHLIENS KVKLLRNQRF PASYHHAVET VVNMLMPHIT
QKFRDNPEAS KNANHSLAVF IKRCFTFMDR GFVFKQINNY ISCFAPGDPK TLFEYKFEFL
RVVCNHEHYI PLNLPMPFGK GRIQRYQDLQ LDYSLTDEFC RNHFLVGLLL REVGTALQEF
REVRLIAISV LKNLLIKHSF DDRYASRSHQ ARIATLYLPL FGLLIENVQR INVRDVSPFP
VNAGMTVKDE SLALPAVNPL VTPQKGSTLD NSLHKDLLGA ISGIASPYTT STPNINSVRN
ADSRGSLIST DSGNSLPERN SEKSNSLDKH QQGSTLGNSV VRCDKLDQSE IKSLLMCFLY
ILKSMSDDAL FTYWNKASTS ELMDFFTISE VCLHQFQYMG KRYIARTGMM HARLQQLGSL
DNSLTFNHSY GHSDADVLHQ SLLEANIATE VCLTALDTLS LFTLAFKNQL LADHGHNPLM
KKVFDVYLCF LQKHQSETAL KNVFTALRSL IYKFPSTFYE GRADMCAALC YEILKCCNSK
LSSIRTEASQ LLYFLMRNNF DYTGKKSFVR THLQVIISVS QLIADVVGIG GTRFQQSLSI
INNCANSDRL IKHTSFSSDV KDLTKRIRTV LMATAQMKEH ENDPEMLVDL QYSLAKSYAS
TPELRKTWLD SMARIHVKNG DLSEAAMCYV HVTALVAEYL TRKGMFRQGC TAFRVITPNI
DEEASMMEDV GMQDVHFNED VLMELLEQCA DGLWKAERYE LIADIYKLII PIYEKRRDFE
RLAHLYDTLH RAYSKVTEVM HSGRRLLGTY FRVAFFGQGF FEDEDGKEYI YKEPKLTPLS
EISQRLLKLY SDKFGSENVK MIQDSGKVNP KDLDSKYAYI QVTHVIPFFD EKELQERKTE
FERSHNIRRF MFEMPFTQTG KRQGGVEEQC KRRTILTAIH CFPYVKKRIP VMYQHHTDLN
PIEVAIDEMS KKVAELRQLC SSAEVDMIKL QLKLQGSVSV QVNAGPLAYA RAFLDDTNTK
RYPDNKVKLL KEVFRQFVEA CGQALAVNER LIKEDQLEYQ EEMKANYREM AKELSEIMHE
QICPLEEKTS VLPNSLHIFN AISGTPTSTM VHGMTSSSSV V
//
