ID A0A2K5NER7_CERAT Unreviewed; 1732 AA.
AC A0A2K5NER7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Methyl-CpG binding domain protein 5 {ECO:0000313|Ensembl:ENSCATP00000036002.1};
GN Name=MBD5 {ECO:0000313|Ensembl:ENSCATP00000036002.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000036002.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000036002.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011893707.1; XM_012038317.1.
DR RefSeq; XP_011893708.1; XM_012038318.1.
DR RefSeq; XP_011893709.1; XM_012038319.1.
DR RefSeq; XP_011893710.1; XM_012038320.1.
DR RefSeq; XP_011893711.1; XM_012038321.1.
DR RefSeq; XP_011893714.1; XM_012038324.1.
DR RefSeq; XP_011893715.1; XM_012038325.1.
DR RefSeq; XP_011893716.1; XM_012038326.1.
DR RefSeq; XP_011893717.1; XM_012038327.1.
DR RefSeq; XP_011893718.1; XM_012038328.1.
DR RefSeq; XP_011893719.1; XM_012038329.1.
DR RefSeq; XP_011893720.1; XM_012038330.1.
DR RefSeq; XP_011893721.1; XM_012038331.1.
DR RefSeq; XP_011893722.1; XM_012038332.1.
DR STRING; 9531.ENSCATP00000036002; -.
DR Ensembl; ENSCATT00000060290.1; ENSCATP00000036002.1; ENSCATG00000040834.1.
DR GeneID; 105575956; -.
DR KEGG; caty:105575956; -.
DR CTD; 55777; -.
DR GeneTree; ENSGT00530000064137; -.
DR OrthoDB; 5404763at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000040834; Expressed in cerebellum and 11 other cell types or tissues.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd20141; PWWP_MBD5; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR000313; PWWP_dom.
DR PANTHER; PTHR16112; METHYL-CPG BINDING PROTEIN, DROSOPHILA; 1.
DR PANTHER; PTHR16112:SF18; METHYL-CPG-BINDING DOMAIN PROTEIN 5; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 11..81
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1623..1647
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 123..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1392..1416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1583..1613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1706..1732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..346
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1732 AA; 184288 MW; 0ACFC6761BED5CF9 CRC64;
MNGGKECDGG DKEGGLPAIQ VPVGWQRRVD QNGVLYVSPS GSLLSCLEQV KTYLLTDGTC
KCGLECPLIL PKVFNFDPGA AVKQRTAEDV KADEDVTKLC IHKRKIIAVA TLHKSMEAPH
PSLVLTSPGG GTNATPVVPS RAATPRSVRN KSHEGITNSV MPECKNPFKL MIGSSNAVGR
LYVQELPGSQ QQELHPVYPR QRLGSSEHGQ KSPFRGSHGG LPSPASSGSQ IYGDGSISPR
TDPLGSPDVF TRNNPGFHGA PNSSPIHLNR TPLSPPSVML HGSPVQSSCA MAGRTNIPLS
PTLTTKSPVM KKPMCNFSTN MEIPRAMFHH KPPQGPPPPP PPSCALQKKP LTSEKDPLGI
LDPIPSKPVN QNPVIINPTS FHSNVHSQVP MMNVSMPPAV VPLPSNLPLP TVKPGHMNHG
SHVQRVQHSA STSLSPSPVT SPVHMMGTGI GRIEASPQRS RSSSTSSDHG NFMMPPVGPQ
ATCSGIKVPP RSPRSTIGSP RPSMPSSPST KSDGHHQYKD IPNPLIAGIS NVLNTPSSAA
FPTASAGSGS VKSQPGLLGM PLNQILNQHN AASFPASSLL SAAAKAQLAN QNKLAGNNSS
SSSNSGAVAG SGNTEGHSTL NTMFPPTASM LLPTGEGQSG RAALRDKLMS QQKDSLRKRK
QPPTTVLSLL RQSQMDSSAV PKPGPDLLRK QGQGSFPISS MSQLLQSMSC QSSHLSSNST
PGCGASNTAL PCSANQLHFT DPSMNSSVLQ NSLTQNIPLR GEAVHCHNAN TNFVHSNSPV
PNHHLAGLIN QIQASGNCGM LSQSGMALGN SLHPNPPQSR ISTSSTPVIP NSIVSSYNQT
SSEAGGSGPS SSIAIAGTNH PAITKTTSVL QDGVIVTTAA GNPLQSQLPI GSDFPFVGQE
HALHFPSNST SNNHLPHPLN PSLLSSLPIS LPVNQQHLLN QNLLNILQPS AGEGKSEINL
HPLGFLDPNV NAALAFLSSD MDGQVLQPVH FQLLAALLQN QAQAAAMLPL PSFNLTISDL
FQQQNTPLPS LTQMTAPPDH LPSNQSDNSR AETLLTSPLG NPLPSFAGSD TTFNPLFLPP
VSGASGLMTL NPQLLGGVLN SALANTANHP EVSIATSSQA TTTTTTTSSA VAALTVSTLG
GTAVVSMAET LLNISNNAGN TPGSAKLNSN SVVPQLLNPL LGTGLLGDMS SINNTLNNHQ
LTHLQSLLNN NQMFPPNQQQ QQLLQGYQNL QAFQGQPTIP CPANNNPMAC LFQNFQVRMQ
EDAALLNKRI STQPGLTALP ENPNTTLPPF QDTPCELQPR IDPSLGQQVK DGLVVGGPGD
ASVDAIYKAV VDAASKGMQV VITTAVNSTT QISPIPALSA MSAFTASIGD PLNLSSAVSA
VIHGRNMGGV DHDGRLRNSR GVRLPKNLDH GKNANEGDGF EYFKSASCHT SKKQWDGEQS
PRGERNRWKY EEFLDHPGHI HSSPCHERSN NVSTLPFLPG EQHPILLPPR NCPGDKILEE
NFRYNNYKRT MMSFKERLEN TVERCAHING NRPRQSRGFG ELLSTAKQDL VLEEQSPSSS
NSLENSLVKD YIHYNGDFNA KSINGCVPSP SDAKSISSED DLRNPDSPSS NELIHYRPRT
FNVGDLVWGQ IKGLTSWPGK LVREDDVHNS CQQSPEEGKV EPEKLKTLTE GLEAYSRVRK
RNRKSGKLNN HLEAAIHEAM SELDKMSGTV HQIPQGDRQM RPPKPKRRKI SR
//
