ID   A0A2K5NG26_CERAT        Unreviewed;       323 AA.
AC   A0A2K5NG26;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Adenosine deaminase {ECO:0000256|ARBA:ARBA00018099};
DE            EC=3.5.4.4 {ECO:0000256|ARBA:ARBA00012784};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000036376.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000036376.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC       Cell membrane {ECO:0000256|ARBA:ARBA00004296}; Peripheral membrane
CC       protein {ECO:0000256|ARBA:ARBA00004296}; Extracellular side
CC       {ECO:0000256|ARBA:ARBA00004296}. Cytoplasmic vesicle lumen
CC       {ECO:0000256|ARBA:ARBA00004321}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   AlphaFoldDB; A0A2K5NG26; -.
DR   Ensembl; ENSCATT00000060666.1; ENSCATP00000036376.1; ENSCATG00000040985.1.
DR   GeneTree; ENSGT00950000183113; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000040985; Expressed in cerebellum and 2 other cell types or tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0060205; C:cytoplasmic vesicle lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF43; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT   DOMAIN          10..189
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   323 AA;  36928 MW;  408661DC28A1F6FB CRC64;
     MTQTPAFNKP KVELHVHLDG AIKPETILYY GRRRGIALPA NTTEGLLNVI GMDKLLTLLD
     FLAKFDYYMP VIAGCREAIK RITYEFIEMK AKEGVVYVEV RYSPHLLANS KVEPIPWNQA
     EGDLTPDEVV ALVGQDFGVK AWSILCCMRH QPNWSPDVTV VAIDLAGDET IPGSSLLPGH
     VQAYQEAVDI LKTERLGHGY HTLEEQALYD RLWQENMHFE ICPWSSYLTG AWKPDTEHAV
     VWLKNDQANY SLNTDDPLIF KYPLDTDYHM TKWDMGFTEE EFKRLNINAV KSSFLPEDEK
     RELLNLLYKA YWMPPSASAG HHL
//