ID A0A2K5NHP7_CERAT Unreviewed; 2724 AA.
AC A0A2K5NHP7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein prune homolog 2 {ECO:0000256|ARBA:ARBA00039860};
DE AltName: Full=BNIP2 motif-containing molecule at the C-terminal region 1 {ECO:0000256|ARBA:ARBA00042084};
GN Name=PRUNE2 {ECO:0000313|Ensembl:ENSCATP00000036952.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000036952.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000036952.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSCATT00000061248.1; ENSCATP00000036952.1; ENSCATG00000041249.1.
DR GeneTree; ENSGT00940000154422; -.
DR OMA; WMDAKQP; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000041249; Expressed in pituitary gland and 11 other cell types or tissues.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR InterPro; IPR022181; Bcl2-/adenovirus-E1B.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR PANTHER; PTHR12112; BNIP - RELATED; 1.
DR PANTHER; PTHR12112:SF11; PROTEIN PRUNE HOMOLOG 2; 1.
DR Pfam; PF12496; BNIP2; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 2531..2692
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1151..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1269..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1379..1455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1520..1560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1576..1601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1655..1691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1722..1862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1876..1903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2127..2176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2223..2267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2324..2344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2376..2401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2413..2433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2449..2468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2476..2511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..845
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1092
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1317..1332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1387..1416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1520..1550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1655..1669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1733..1748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1749..1763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1776..1790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1815..1847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1876..1901
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2148..2176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2376..2396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2480..2495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2724 AA; 298569 MW; 6B615BBC002CC001 CRC64;
MVSNSRTSST EAVAGSAPLS QGSSGIMELY GSDVEPQPSS VNFIENPPDL NDSNQAQVDA
NVDLVSPDSG LATIRSSRSS KESSVFLSDD SPVGEGAGPH HTLLPGLDSY SPIPEGAVAE
EHAWSGEHGE HFDLFNFDPA PMASGQSQQS SHSADYSPAD DFFPNSDLSE GQLPAGPDGL
DGMGTNMSNY SSTSLLSGAG KDSLVEYDEE FVQRQESPRD NSERNLSLTD FVGDESPSPE
RLKNIGKRIP PTPMNSLVES SPSTEEPASL YTEDMTQKAT DTGHMGPPQT HARCSSWWGG
LEIDSKNVAD AWSSSERESV FQSPESWKEH KPSSIDRRAS DSVFQPKSLE FTKSGPWESE
FGQPELGSND IQDQNEESLS FQNVPMEKPP LPNTSPQGTN HLIEDFASLW HSGRSPTAMP
EPWGNPTDDG EPAAAAPFPA WSAFGKEDHA EALKNTWNLH PTSGETPSVR DPNEWAMAKG
GFVFSSSELL DTSPSEINNE AAPEIWGKRN NDSRDHIFAP GNPSSDLDHT WTNSKPPKED
QNGLVDPKTR GKVYEKVDSW NLFEESMKKG GSDVLAPWED SFLSYKCSDY SASNLGEDSV
PSPLDTNYST SDSYTSPTCA GDEKETEHKP FAKEEGFESK DGNSTAEETD IPPQSLQQPS
RNRISSGPGN LDMWASPHTD NSSEINATHD PDENELKTEH TDGKNVSMED DVGESSQSSY
DDPSMMQLYN ETNRQLTLLH SSTNSRQTAP DSLDLWNRVI LEDTQSTATI SDMDNDLDWD
DCSGGVALPT DGQTEGYMAE STEPETRFTV RQLEPWGLEY QEANQVDWEL PASDEHTKDS
APSGHHTLNE KSGQLIANSI WDSVMRDKDM SSFMLPGSSY LTDSEQSELP SEIPSHSANV
KDTHCPDAPA ASGTSESGAL ISHLDNQETE RETLQSDAAS LATRLENPGH FAHPDPWKGH
SNGQSESEKE AQGATNREHL DEEEVIASGV ESASGISEKG QSDQELSSLV ASEHQEICVK
SGKISSLAVT FSPQTEEPEE VSEYEKGSYN LDSRDVQTGM SADNLQPEDT YEQNLMSQRN
SGETTETSDG MNFPKYVSVP EKNLEKTEAC NILEPENVGG GGPHKVPQSL DFGDAPVDSV
VHVSCTSSEI TKNLDVKGTE NSLPGASSSG NFDRDTISSE YTHSSASSPE LNDSSVALSS
WGQQPSSGYQ EENRGNWSEQ NHQESELITT DGQVEIVTKM KDLEKNRTNE FEKSLDRKTP
TFLEIWNDSI DGDSLSSLSS PETGRYSEHS GTRQESNLIA SYQEKNEHDI SATVQPKDAR
AISTSSGSDD DSVGGEESVE EEIQAANCHV AQDESRAWES LNESNKFLVT ADPKSENIYD
YLGSSEPAEN ESKSNPFCDN QQSSPDHWNF SPLTETEIQV PAVEKEMRSS PETGKTGDVA
WQISPKAEPK NEDNSQLEML GFSADSTEWW NALPQEGRLI ESTSERELSD PSDVLEINSS
VYQNASPWGV PVQNDIEPVE THYTNPFSDN HQSPFLEGNG KNSHEQLWNI QPRQPDPDAD
KFSQLVILDQ IKEKDSREQT FVSAAGDELT PETPTQERRQ DAMLSVCDQP DAAFTHAEEN
GCVTSNVSTN EGQETNQWEQ EKSYLGEMTH SSIATENFPA VSSPTQLIMK PGSEWDGSAP
NEDSQGTFVP DILHGNFQEG GQLASAAPDL WVDAKKPFSL KADGENPDIL THCDHDSNSQ
ASNSPDICHD SEAKQDTEKH LGACMGPEVE SSELCLTEPE MDKEPIHEPG QEFVPSDAEL
DSENATPLPP IGNQADIKGS SQPASHKGSP EPSEINSDDN TDLQASEKGA SPDMAPILEP
VDRRIPRIEN VATSIFVTHQ EPTPEGDSSW LSDSFSPESQ SGARALFDGE PRLSTENPAM
VPDALLASDT CLDISEAAFD HSFSDASGLN TSTGTIDDMS KLTLSEGHPE TPVDGDLAKQ
DICSSEASWG DFEYDVMGQN IDEDLLREPE HFLYGGDPPL EEDSLKQSLA PYTPPFDLSY
LTEPAQSAET IEEAGSPEDE SLGYRAAEIV LSALPDRRSE VNQAETKNRL PGSQLTVLHI
HEDPESVYLP VGAGANILSP SSIDWEVETD NSDLPAGGDI GPPNGDSKEI SELEEEKVIP
TKEPEQIKSE YKEGRCTEKN EDRHVLHMDY ILVNHEENLH SKPEACEERE SIAELELYVG
SKETGPQGTQ LASFPDTCQP ASLNETKGIS AEKMSSKGDT SSSFESPAQD QSWMFLGHSE
VGDLSSGPGW SGKTVEPFSE LSLGEGPQLQ ILQEMKPLES LALEEASGPV SQSQKSKSRG
RADPDAVMLQ AVTHDNEWEM LSPQPAQKTM IRDTEMEEET EFLELGTRKP RPHGLLSEDV
GMDIPFEEGV LSPSAADMRP EPPNSLDLNG THPRRIKLTA PNINLSLDQS EGSILSDDNL
DSPDEIDINV DELDTPDEAD SFEYTGHEDP TANKDSGQES ESIPEYTAEE EREDNRLWRT
VVIGEQEQRI DMKVIEPYRR VISHGGYYGD GLNAIIVFAA CFLPDSGRAD YHYVMENLFL
YVISTLELMV AEDYMIVYLN GATPRRKMPG LGWMKKCYQM IDRRLRKNLK SFIIVHPSWF
IRTILAVTRP FISSKFSSKI KYVNSLSELS GLIPMDCIHI PESIIKLDEE LREASEAAKT
SCLYNDPEMS SMEKDIDLKL KEKP
//
