ID A0A2K5NI31_CERAT Unreviewed; 868 AA.
AC A0A2K5NI31;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Endothelial PAS domain protein 1 {ECO:0000313|Ensembl:ENSCATP00000037075.1};
GN Name=EPAS1 {ECO:0000313|Ensembl:ENSCATP00000037075.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000037075.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000037075.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
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DR AlphaFoldDB; A0A2K5NI31; -.
DR Ensembl; ENSCATT00000061371.1; ENSCATP00000037075.1; ENSCATG00000041291.1.
DR GeneTree; ENSGT00940000155930; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000041291; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0001666; P:response to hypoxia; IEA:UniProt.
DR CDD; cd19728; bHLH-PAS_HIF2a_PASD2; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR014887; HIF-1_CTAD.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR23043:SF8; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF08778; HIF-1a_CTAD; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 13..66
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 91..146
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 248..299
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 404
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 529
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 845
FT /note="(3S)-3-hydroxyasparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
SQ SEQUENCE 868 AA; 96138 MW; 2C9BFCFBE8F86B70 CRC64;
QTQNKQKQSS SERRKEKSRD AARCRRSKET EVFYELAHEL PLPHSVSSHL DKASIMRLAI
SFLRTHKLLS SVCSENESEA EADQQMDNLY LKALEGFIAV VTQDGDMIFL SENISKFMGL
TQVELTGHSI FDFTHPCDHE EIRENLSLKN GSGFGKKSKD MSTERDFFMR MKCTVTNRGR
TVNLKSATWK VLHCTGQVKV YNNCPPHNSL CGYKEPLLSC LIIMCEPIQH PSHMDIPLDS
KTFLSRHSMD MKFTYCDDRI TELIGYHPEE LLGRSAYEFY HALDSENMTK SHQNLCTKGQ
VVSGQYRMLA KHGGYVWLET QGTVIYNPRN LQPQCIMCVN YVLSEIEKND VVFSMDQTES
LFKPHLMAMN SIFDSSGKGA VSEKSNFLFT KLKEEPEELA QLAPTPGDAI ISLDFGNQNF
EESSAYGKAI LPPSQPWATE LRSHSTQSEA GSLPAFTVPQ AAAPGSTTPS ATSSSSCSTP
NSPEDYYTSL DNDLKIEVIE KLFAMDTEAK DQCSTQTDFN ELDLETLAPY IPMDGEDFQL
SPICPEERLL AENPQSTPQH CFSAMTNIFQ PLAPVAPHSP FLLDKFQQQL ESKKTEPEHR
PMSSIFFDAG SKASLPPCCG QASTPLSSMG GRSNTQWPPD PPLHFGPTKW AVGDQRTEFL
GAAPLGPPVS PPHVSTFKTR SAKGFGARGP DVLSPAMVAL SNKLKLKRQL EYEEQAFQDL
SGGDPPGGST SHLMWKRMKN LRGGSCPLMP DKPLSANVPN GKFTQNPVRG LGHPLRHLPL
PQPPSAVSPG ENSKSRFPAQ CYATQYQDYS LSSAHKVSGM ASRLLGPSFE SYLLPELTRY
DCEVNVPVLG SSTLLQGGDL LRALDQAT
//
