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Database: UniProt
Entry: A0A2K5NJ10_CERAT
LinkDB: A0A2K5NJ10_CERAT
Original site: A0A2K5NJ10_CERAT 
ID   A0A2K5NJ10_CERAT        Unreviewed;      2717 AA.
AC   A0A2K5NJ10;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   05-DEC-2018, entry version 7.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSCATP00000037508};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSCATP00000037508};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000037508, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000037508, ECO:0000313|Proteomes:UP000233060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y., Hughes D.S., Murali S., Raveendran M., Korchina V., Wang M.,
RA   Jhangiani S., Bandaranaike D., Bellair M., Blankenburg K., Chao H.,
RA   Dahdouli M., Dinh H., Doddapaneni H., English A., Firestine M.,
RA   Gross S., Hernandez B., Javaid M., Jayaseelan J., Jones J., Joshi V.,
RA   Khan Z., Kovar C., Lee S., Newsham I., Nguyen L., Okwuonu G.,
RA   Ongeri F., Osuji N., Pu L.-L., Puazo M., Qu C., Quiroz J., Raj R.,
RA   Reid J.G., Santibanez J., Scheel M., Sexton D., Shah N., Skinner E.,
RA   Vee V., Wu Y., Han Y., Muzny D.M., Richards S., Worley K.C.,
RA   Rogers J., Gibbs R.A.;
RT   "Sooty reference genome and diversity panel.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCATP00000037508}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
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DR   Ensembl; ENSCATT00000061805; ENSCATP00000037508; ENSCATG00000041137.
DR   GeneTree; ENSGT00940000155071; -.
DR   Proteomes; UP000233060; Whole Genome Shotgun Assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000233060};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2256   2278       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2290   2308       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2314   2340       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2377   2400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2420   2442       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2538   2561       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    373       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      379    435       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1603   1623       {ECO:0000256|SAM:Coils}.
FT   COILED     2655   2696       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2717 AA;  309962 MW;  6F64F39395CDEB12 CRC64;
     MNTGKLRAEN DFSGHICSCF WSTRDCSTFK SLIQHHCCHT KQKSLNFCLF ALLLDCLFKL
     CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV
     RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE
     GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT
     SPVKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL
     VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE
     LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH
     NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT
     NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF WRDSNKEIRS KSVRELAQDA
     KEGQKEDRDV LSYYRYQLNL FARMCLDRQY LAINEISGQL DVDLILRCMS DENLPYDLRA
     SFCRLMLHMH VDRDPQEQVT PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF
     VEEYLRDVVC QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH
     VTTIFPISKM AKGEENKGNN DVEKLKSSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA
     PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQTSE
     TSSGNSSQEG PSNVPGALDF EHIEEQAEGI FGGRKENTPL DLDDHGGRTF LRVLLHLTMH
     DYPPLVSGAL QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE
     LWVYKGQGPD ETMDGASGEN GHKKTEEGNN KSQKHESTSS YNYRVVKEIL IRLSKLCVQE
     SASVRKSRKQ QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ
     NQALLHKHIN LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK
     FLQTIVKAEG KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP
     LMYHIHLVEL LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT HEDCIPEVKI AYINFLNHCY
     VDTEVEMKEI YTSNHMWKLF ENFLVDICRA CNNTSDRKHA DSILEKYVTE IVMSIVTTFF
     SSPFSDQSTT LQTRQPVFVQ LLQGVFRVYH CNWLMPSQKA SVESCIRVLS DVAKSRAIAI
     PVDLDSQVNN LFLKSHNIVQ KTAMNWRLSA RNAARRDSVL AASRDYRNII ERLQDIVSAL
     EDRLRPLVQA ELSVLVDVLH RPELLFPENT DARRKCESGG FICKLIKHTK QLLEENEEKL
     CIKVLQTLRE MMTKDRGYGE KVLHFIFMVK PGFGEALRQI LVNRYYGNIR PSGRRESLTS
     FGNGPLSPGG PSKPGGGGGG SGSSSMSRGE MSLAEVQCHL DKEGASNLVI DLIMNASSDR
     VFHESILLAI ALLEGGNTTI QHSFFCRLTE DKKSEKFFKV FYDRMKVAQQ EIKATVTVNT
     SDLGNKKKDD EVDRDAPSRK KAKEPTTQIT EEVRDQLLEA SAATRKAFTT FRREADPDDH
     YQPGEGTQAT ADKTKDDLEM SAVITIMQPI LRFLQLLCEN HNRDLQNFLR CQNNKTNYNL
     VCETLQFLDC ICGSTTGGLG LLGLYINEKN VALINQTLES LTEYCQGPCH ENQNCIATHE
     SNGIDIITAL ILNDINPLGK KRMDLVLELK NNASKLLLAI MESRHDSENA ERILYNMRPK
     ELVEVIKKAY MQGEVEFEDG ENGEDGAASP RNVGHNIYIL AHQLARHNKE LQSMLKPGGQ
     VDGDEALEFY AKHTAQIEIV RLDRTMEQIV FPVPSICEFL TKESKLRIYY TTERDEQGSK
     INDFFLRSED LFNEMNWQKK LRAQPVLYWC ARNMSFWSSI SFNLAVLMNL LVAFFYPFKG
     VRGGTLEPHW SGLLWTAMLI SLAIVIALPK PHGIRALIAS TILRLIFSVG LQPTLFLLGA
     FNVCNKIIFL MSFVGNCGTF TRGYRAMVLD VEFLYHLLYL VICAMGLFVH EFFYSLFDLV
     YREETLLNVI KSVTRNGRSI ILTAVLALIL VYLFSIVGYL FFKDDFILEV DRLLASEFLF
     SDVCRVESGE NCSSPAPKEE LVPAEETEQD KEHTCETLLM CIVTVLSHGL RSGGGVGDVL
     RKPSKEEPLF AARVIYDLLF FFMVIIIVLN LIFGVIIDTF ADLRSEKQKK EEILKTTCFI
     CGLERDKFDN KTVTFEEHIK EEHNMWHYLC FIVLVKVKDS TEYTGPESYV AEMIKERNLD
     WFPRMRAMSL VSSDSEGEQN ELRNLQEKLE STMKLVTNLS GQLSELKDQM TEQRKQKQRI
     GLLGHPPHMN VNPQQPA
//
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