ID   A0A2K5NK91_CERAT        Unreviewed;       159 AA.
AC   A0A2K5NK91;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Immunity related GTPase M {ECO:0000313|Ensembl:ENSCATP00000037954.1};
GN   Name=IRGM {ECO:0000313|Ensembl:ENSCATP00000037954.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000037954.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000037954.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. IRG family. {ECO:0000256|ARBA:ARBA00005429}.
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DR   AlphaFoldDB; A0A2K5NK91; -.
DR   STRING; 9531.ENSCATP00000037954; -.
DR   Ensembl; ENSCATT00000062255.1; ENSCATP00000037954.1; ENSCATG00000041689.1.
DR   GeneTree; ENSGT00950000183007; -.
DR   OMA; KEQVCEH; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000041689; Expressed in adult mammalian kidney.
DR   GO; GO:0000421; C:autophagosome membrane; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0051434; F:BH3 domain binding; IEA:Ensembl.
DR   GO; GO:0050700; F:CARD domain binding; IEA:Ensembl.
DR   GO; GO:0003925; F:G protein activity; IEA:Ensembl.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR   GO; GO:0000045; P:autophagosome assembly; IEA:Ensembl.
DR   GO; GO:0061762; P:CAMKK-AMPK signaling cascade; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR   GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0160049; P:negative regulation of cGAS/STING signaling pathway; IEA:Ensembl.
DR   GO; GO:0050687; P:negative regulation of defense response to virus; IEA:Ensembl.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:1900226; P:negative regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
DR   GO; GO:0032480; P:negative regulation of type I interferon production; IEA:Ensembl.
DR   GO; GO:0070431; P:nucleotide-binding oligomerization domain containing 2 signaling pathway; IEA:Ensembl.
DR   GO; GO:1901098; P:positive regulation of autophagosome maturation; IEA:Ensembl.
DR   GO; GO:1905673; P:positive regulation of lysosome organization; IEA:Ensembl.
DR   GO; GO:1901526; P:positive regulation of mitophagy; IEA:Ensembl.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR   GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
DR   GO; GO:0060335; P:positive regulation of type II interferon-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1904417; P:positive regulation of xenophagy; IEA:Ensembl.
DR   GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
DR   GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR   GO; GO:0071211; P:protein targeting to vacuole involved in autophagy; IEA:Ensembl.
DR   GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR   GO; GO:0061635; P:regulation of protein complex stability; IEA:Ensembl.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR030385; G_IRG_dom.
DR   InterPro; IPR007743; Immunity-related_GTPase-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR32341:SF9; IMMUNITY-RELATED GTPASE FAMILY M PROTEIN; 1.
DR   PANTHER; PTHR32341; INTERFERON-INDUCIBLE GTPASE; 1.
DR   Pfam; PF05049; IIGP; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51716; G_IRG; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT   DOMAIN          10..159
FT                   /note="IRG-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51716"
SQ   SEQUENCE   159 AA;  17605 MW;  5ECF481360115972 CRC64;
     EKALVGGNLP EVASAIKETL KIVSRTPVNI AMAGTLAGKP SPPTGLVKAT QRCAPYFSSH
     FPNVVLWDLP GTGSATKTLE NYLMEMQFNQ YDFIMVASAQ FSMNHVMLAK TTEDMGKKFY
     IVWTKLDMDL STGALPEVQL LQIRENVLEN LQKEQVCEH
//