ID A0A2K5NL84_CERAT Unreviewed; 547 AA.
AC A0A2K5NL84;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=RAR related orphan receptor A {ECO:0000313|Ensembl:ENSCATP00000038289.1};
GN Name=RORA {ECO:0000313|Ensembl:ENSCATP00000038289.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000038289.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000038289.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR AlphaFoldDB; A0A2K5NL84; -.
DR Ensembl; ENSCATT00000062593.1; ENSCATP00000038289.1; ENSCATG00000041834.1.
DR GeneTree; ENSGT00940000157387; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000041834; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR CDD; cd06968; NR_DBD_ROR; 1.
DR CDD; cd06939; NR_LBD_ROR_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR044101; NR_DBD_ROR.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR003079; ROR_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR45805; NUCLEAR HORMONE RECEPTOR HR3-RELATED; 1.
DR PANTHER; PTHR45805:SF3; NUCLEAR RECEPTOR ROR-ALPHA; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01293; RORNUCRECPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 94..169
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 296..534
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 180..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 62154 MW; C14FEC999861988A CRC64;
MNEGTPGGSD LETEARVLWS VMGHCLTGQA KMSATPTPAG EGARSSPTYS SLSRLFWSQL
EHINRDGATA ENFINLWEFF SFLLPVLRKA QIEIIPCKIC GDKSSGIHYG VITCEGCKGF
FRRSQQSNAT YSCPRQKNCL IDRTSRNRCQ HCRLQKCLAV GMSRDAVKFG RMSKKQRDSL
YAEVQKHRMQ QQQRDHQQQP GEAEPLTPTY NISANGLTEL HDDLSNYIDG HTPEGSKADS
AVSSFYLDIQ PSPDQSGLDI NGIKPEPICD YTPASGFFPY CSFTNGETSP TVSMAELEHL
AQNISKSHLE TCQYLREELQ QITWQTFLQE EIENYQNKQR EVMWQLCAIK ITEAIQYVVE
FAKRIDGFME LCQNDQIVLL KAGSLEVVFI RMCRAFDSQN NTVYFDGKYA SPDIFKSLGC
EDFISFVFEF GKSLCSMHLT EDEIALFSAF VLMSADRSWL QEKVKIEKLQ QKIQLALQHV
LQKNHREDGI LTKLICKVST LRALCGRHTE KLMAFKAIYP DIVRLHFPPL YKELFTSEFE
PAMQIDG
//
