ID A0A2K5NLT4_CERAT Unreviewed; 468 AA.
AC A0A2K5NLT4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=RAR related orphan receptor A {ECO:0000313|Ensembl:ENSCATP00000038291.1};
GN Name=RORA {ECO:0000313|Ensembl:ENSCATP00000038291.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000038291.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000038291.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR RefSeq; XP_011948289.1; XM_012092899.1.
DR AlphaFoldDB; A0A2K5NLT4; -.
DR Ensembl; ENSCATT00000062595.1; ENSCATP00000038291.1; ENSCATG00000041834.1.
DR GeneID; 105601071; -.
DR CTD; 6095; -.
DR GeneTree; ENSGT00940000157387; -.
DR OrthoDB; 3475284at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000041834; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR CDD; cd06968; NR_DBD_ROR; 1.
DR CDD; cd06939; NR_LBD_ROR_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR044101; NR_DBD_ROR.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR003079; ROR_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR45805; NUCLEAR HORMONE RECEPTOR HR3-RELATED; 1.
DR PANTHER; PTHR45805:SF3; NUCLEAR RECEPTOR ROR-ALPHA; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01293; RORNUCRECPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 15..90
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 217..455
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 101..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 468 AA; 53554 MW; 536C3163B2A10F3F CRC64;
MMYFVIAAMK AQIEIIPCKI CGDKSSGIHY GVITCEGCKG FFRRSQQSNA TYSCPRQKNC
LIDRTSRNRC QHCRLQKCLA VGMSRDAVKF GRMSKKQRDS LYAEVQKHRM QQQQRDHQQQ
PGEAEPLTPT YNISANGLTE LHDDLSNYID GHTPEGSKAD SAVSSFYLDI QPSPDQSGLD
INGIKPEPIC DYTPASGFFP YCSFTNGETS PTVSMAELEH LAQNISKSHL ETCQYLREEL
QQITWQTFLQ EEIENYQNKQ REVMWQLCAI KITEAIQYVV EFAKRIDGFM ELCQNDQIVL
LKAGSLEVVF IRMCRAFDSQ NNTVYFDGKY ASPDIFKSLG CEDFISFVFE FGKSLCSMHL
TEDEIALFSA FVLMSADRSW LQEKVKIEKL QQKIQLALQH VLQKNHREDG ILTKLICKVS
TLRALCGRHT EKLMAFKAIY PDIVRLHFPP LYKELFTSEF EPAMQIDG
//
